The official journal of the Brazilian Diabetes Society.
Articles
Page 5 of 51
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Citation: Diabetology & Metabolic Syndrome 2025 17:92
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Identification of variants in exon 4 of the LDLR gene and assessment of their effects on the produced proteins in saudi women with metabolic syndrome
Genetic factors might influence metabolic syndrome (MetS) or any of its components. It was postulated that low density lipoprotein receptor (LDLR) gene variants could play a role in cholesterol hemostasis and the...
Citation: Diabetology & Metabolic Syndrome 2025 17:91 -
Prognostic impact of prediabetes on long-term cardiovascular outcomes in patients under 35 with premature acute myocardial infarction
Prediabetes (pre-DM) is recognized as an intermediate state of glucose metabolism with a high potential to progress to diabetes mellitus (DM). However, its prognostic value in patients with premature acute myo...
Citation: Diabetology & Metabolic Syndrome 2025 17:90 -
Exploring the interplay between adipokine-mediated celastrol target genes and T cells in diabetic nephropathy: a mendelian randomization-based causal inference
Diabetic nephropathy (DN) is influenced by dysregulated adipokines, which play a key role in inflammation, immune responses, and lipid metabolism. However, the precise molecular mechanisms linking adipokine dy...
Citation: Diabetology & Metabolic Syndrome 2025 17:89 -
Body mass index modifies the major adverse cardiovascular and cerebral events risk of NT-proBNP in patients with acute coronary syndrome
Little is known about the relationship between body mass index (BMI) and the prognostic value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients with acute coronary syndrome (ACS). This study...
Citation: Diabetology & Metabolic Syndrome 2025 17:88 -
Association between the haemoglobin glycation index and 30-day and 365-day mortality in patients with heart failure admitted to the intensive care unit
The hemoglobin glycation index (HGI) represents the difference between the observed and predicted values of haemoglobin A1c (HbA1c). However, the association between HGI and prognosis of heart failure (HF) is ...
Citation: Diabetology & Metabolic Syndrome 2025 17:87 -
Disturbances in the gut microbiota potentially associated with metabolic syndrome among patients living with HIV-1 and on antiretroviral therapy at Bafoussam Regional Hospital, Cameroon
This study investigates the gut microbiota components associated with metabolic syndrome in patients living with HIV-1 at Bafoussam Regional Hospital, West Cameroon, it focuses on gastrointestinal mucosal barr...
Citation: Diabetology & Metabolic Syndrome 2025 17:86 -
U-shaped relationship of estimated glucose disposal rate with cardiovascular disease risk in cardiovascular-kidney-metabolic syndrome stages 0–3: a population-based prospective study
Cardiovascular-Kidney-Metabolic (CKM) syndrome is characterized by the interrelatedness of chronic kidney disease (CKD), cardiovascular disease (CVD), and metabolic disorders. The relationship between estimate...
Citation: Diabetology & Metabolic Syndrome 2025 17:85 -
Recent advances in understanding the mechanisms by which sodium-glucose co-transporter type 2 inhibitors protect podocytes in diabetic nephropathy
Diabetes mellitus is associated with systemic damage across multiple organ systems, and an increasing number of patients are presenting with diabetic kidney disease as its initial manifestation. The onset and ...
Citation: Diabetology & Metabolic Syndrome 2025 17:84 -
Association of obesity and LDL subfractions evaluated by body mass index, waist circumference, and diabetes status: the ELSA-Brasil study
Low-density lipoproteins (LDL) comprise a pool of particles with different densities that may have variable impact on atherogenesis. Studies suggest that obese individuals with elevated body mass index (BMI) a...
Citation: Diabetology & Metabolic Syndrome 2025 17:83 -
GABA and GLP-1 receptor agonist combination therapy modifies diabetes and Langerhans islet cytoarchitecture in a rat model of Wolfram syndrome
Wolfram syndrome (WS) is a rare autosomal disorder caused by WFS1 gene mutations, currently lacking approved treatments. Preclinical and clinical reports suggest that diabetes medications, such as glucagon-lik...
Citation: Diabetology & Metabolic Syndrome 2025 17:82 -
Association between metabolic visceral fat score and left ventricular hypertrophy in individuals with type 2 diabetes
Left ventricular hypertrophy (LVH), a hallmark of early-stage heart failure (HF), is a common complication in individuals with type 2 diabetes mellitus (T2DM). Metabolic Visceral Fat Score (METS-VF), a novel m...
Citation: Diabetology & Metabolic Syndrome 2025 17:81 -
The causal effect of glaucoma and diabetic retinopathy: a Mendelian randomization study
Previous research showed that there is an important association between glaucoma and diabetic retinopathy (DR). However, the relationship has not been clarified. In this study, we attempted to evaluate it.
Citation: Diabetology & Metabolic Syndrome 2025 17:80 -
Effect of high-dose N-acetyl cysteine on the clinical outcome of patients with diabetic peripheral neuropathy: a randomized controlled study
Diabetic peripheral neuropathy (DPN) is a vastly common and bothersome disorder with a clinically challenging course of treatment affecting patients with diabetes. This study aimed to evaluate the efficacy and...
Citation: Diabetology & Metabolic Syndrome 2025 17:79 -
Brazilian guideline for screening and diagnosis of type 2 diabetes: a position statement from the Brazilian Diabetes Society
Patients with type 2 diabetes (T2D) often experience prolonged periods of asymptomatic hyperglycemia, which significantly increases the risk of developing chronic complications related to diabetes. Screening p...
Citation: Diabetology & Metabolic Syndrome 2025 17:78 -
Association of triglyceride-glucose index with bone mineral density and fracture: a systematic review
Studies have found inconsistent results regarding triglyceride-glucose (TyG) index and bone health. This systematic review aims to synthesize the existing evidence on the association between the (TyG) index, b...
Citation: Diabetology & Metabolic Syndrome 2025 17:77 -
Association between lipoprotein(a) and diabetic peripheral neuropathy in patients with type 2 diabetes: a meta-analysis
Diabetic peripheral neuropathy (DPN) is a common complication of type 2 diabetes (T2D). Lipoprotein(a) [Lp(a)], a known cardiovascular risk factor, has been hypothesized to influence the development of DPN. Th...
Citation: Diabetology & Metabolic Syndrome 2025 17:76 -
Abdominal obesity and frailty progression in population across different Cardiovascular-Kidney-Metabolic syndrome stages: a nationwide longitudinal study
Abdominal obesity, assessed via the body roundness index (BRI), is a critical determinant of health outcomes. This study explores the association between abdominal obesity and frailty progression across differ...
Citation: Diabetology & Metabolic Syndrome 2025 17:75 -
Association between the triglyceride–glucose index and acute kidney injury in patients undergoing percutaneous coronary: a retrospective analysis of the MIMIC-IV database
Acute kidney injury (AKI) is a common complication that affects the outcomes of patients undergoing percutaneous coronary intervention (PCI). The triglyceride–glucose (TyG) index, a metric computed from fastin...
Citation: Diabetology & Metabolic Syndrome 2025 17:74 -
Association between estimated glucose disposal rate with the all-cause and cause-specific mortality among the population with cardiometabolic syndrome
Estimated glucose disposal rate (eGDR) is considered as a reliable alternative indicator of insulin resistance. However, the relationship between eGDR levels and mortality among individuals with cardiometaboli...
Citation: Diabetology & Metabolic Syndrome 2025 17:73 -
Metabolic syndrome including both elevated blood pressure and elevated fasting plasma glucose is associated with higher mortality risk: a prospective study
Metabolic syndrome (MetS) encompasses a collection of metabolic abnormalities. This study aims to determine which combination of MetS components has the highest mortality risk, and to investigate the causal re...
Citation: Diabetology & Metabolic Syndrome 2025 17:72 -
Association of pericoronary inflammation with atherosclerotic plaque progression in diabetic patients with improved modifiable cardiovascular risk factors: a longitudinal CCTA cohort study
Pericoronary adipose tissue (PCAT) attenuation, as assessed by coronary computed tomography angiography (CCTA), has been identified as a marker of pericoronary inflammation and a predictor of future adverse at...
Citation: Diabetology & Metabolic Syndrome 2025 17:71 -
Causal relationship of sleep duration on risks for metabolic syndrome: a Mendelian randomization study
The cluster of cardiovascular risk factors, referred to as metabolic syndrome (MetS), represents a substantial risk factor for cardiovascular diseases and presents a significant public health challenge. Howeve...
Citation: Diabetology & Metabolic Syndrome 2025 17:70 -
Stress hyperglycemia ratio: a novel prognostic marker in chronic kidney disease
The stress hyperglycemia ratio (SHR) has recently been suggested to characterize acute glycemic rise better than the admission blood glucose and to be associated with unfavorable outcomes in patients with vari...
Citation: Diabetology & Metabolic Syndrome 2025 17:69 -
Safety, efficacy, and cardiovascular benefits of combination therapy with SGLT-2 inhibitors and GLP-1 receptor agonists in patients with diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials
The potential benefits and risks of combination therapy with sodium-glucose co-transporter-2 inhibitors (SGLT-2is) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) versus monotherapy remain a subject o...
Citation: Diabetology & Metabolic Syndrome 2025 17:68 -
The role of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (nhhr) in prediabetes progression and the mediating effect of BMI: a longitudinal study in China
Diabetes prevalence in China is significant, with a large proportion in the prediabetes stage. Dyslipidemia is associated with abnormal glucose metabolism, and the non-high-density lipoprotein cholesterol to h...
Citation: Diabetology & Metabolic Syndrome 2025 17:67 -
Lifestyle intervention to prevent type 2 diabetes after a pregnancy complicated by gestational diabetes mellitus: a systematic review and meta-analysis update
Women with prior gestational diabetes mellitus (GDM) are at increased risk of type 2 diabetes, and lifestyle intervention (LSI) offered a decade after pregnancy is effective in preventing diabetes. However, si...
Citation: Diabetology & Metabolic Syndrome 2025 17:66 -
Association between air pollution and cardiovascular disease risk in middle-aged and elderly individuals with diabetes: inflammatory lipid ratio accelerate this progression
Long-term exposure to air pollution significantly increases the risk of cardiovascular disease (CVD); however, the association and underlying mechanisms in individuals with diabetes remain unconfirmed.
Citation: Diabetology & Metabolic Syndrome 2025 17:65 -
Prediction of unfavorable outcome of acute decompensation of diabetes mellitus
Using the method of spectral-probability analysis, to evaluate the possibility of predicting an unfavorable outcome of acute decompensation of diabetes mellitus in patients hospitalized in the intensive care u...
Citation: Diabetology & Metabolic Syndrome 2025 17:64 -
Causal associations between posttraumatic stress disorder and type 2 diabetes
Posttraumatic stress disorder (PTSD) patients have a high comorbidity with type 2 diabetes (T2D). Whether PTSD influences the risk of diabetes is still not known. We used GWAS data from European ancestry of PT...
Citation: Diabetology & Metabolic Syndrome 2025 17:63 -
Diabetes distress and associated psychosocial factors in type 2 diabetes. A population-based cross-sectional study. The HUNT study, Norway
The world-wide prevalence of diabetes distress varies, and studies are mainly undertaken in clinical settings. By using data from the Trøndelag Health (HUNT) study, we aimed to estimate diabetes distress preva...
Citation: Diabetology & Metabolic Syndrome 2025 17:62 -
Elevated levels of PAI-1 precede the occurrence of type 2 diabetes mellitus
Plasminogen activator inhibitor-1 (PAI-1) is the main inhibitor of the fibrinolytic system and is mainly secreted from adipose tissue. It is associated with cardiovascular disease and has also been considered ...
Citation: Diabetology & Metabolic Syndrome 2025 17:61 -
GLP-1-based therapies for type 2 diabetes: from single, dual and triple agonists to endogenous GLP-1 production and L-cell differentiation
Glucagon-like peptide-1 (GLP-1) is an incretin peptide hormone mainly secreted by enteroendocrine intestinal L-cells. GLP-1 is also secreted by α-cells of the pancreas and the central nervous system (CNS). GLP...
Citation: Diabetology & Metabolic Syndrome 2025 17:60 -
Triglyceride glucose-waist circumference as a predictor of mortality and subtypes of cardiovascular disease: a systematic review and meta-analysis
The significant burden of cardiovascular diseases underscores the necessity for identifying novel predictive markers that can forecast both cardiovascular diseases and mortality. In recent years, TyG-obesity-r...
Citation: Diabetology & Metabolic Syndrome 2025 17:59 -
Association between estimated glucose disposal rate and prediction of cardiovascular disease risk among individuals with cardiovascular-kidney-metabolic syndrome stage 0–3: a nationwide prospective cohort study
Insulin resistance is a crucial factor in the development of cardiovascular diseases (CVD), yet the relationship between the estimated glucose disposal rate (eGDR), an index reflecting insulin resistance, and ...
Citation: Diabetology & Metabolic Syndrome 2025 17:58 -
CircRNA-mediated ceRNA regulatory networks: transcriptomic insights into obesity type 2 diabetes progression and treatment strategies
The aim of this study was to deeply explore the pathogenesis of obesity type 2 diabetes mellitus (O-T2DM) and search for potential biomarkers through high-throughput RNA sequencing technology. The study includ...
Citation: Diabetology & Metabolic Syndrome 2025 17:57 -
Fifteen-year trends in diabetes drug management and control in French-speaking Switzerland
Drug management of type 2 diabetes (T2D) should comply with established guidelines. Still, little is known about how drug management of T2D in Switzerland has evolved over time. We aimed at assessing 15-year t...
Citation: Diabetology & Metabolic Syndrome 2025 17:56 -
Anti-glycaemic effect of the Chinese modified DASH diet combined with 23% low-sodium salt in patients with hypertension and type 2 diabetes: a clinical trial
Although many previous trials have formalized the blood glucose-lowering effect of the DASH diet, relevant reports in China remain limited. This study aimed to explore the anti-hyperglycaemic effect of the Chi...
Citation: Diabetology & Metabolic Syndrome 2025 17:55 -
Screening and management of hospital hyperglycemia in non-critical patients: a position statement from the Brazilian Diabetes Society (SBD)
Hospital Hyperglycemia (HH) is linked to poorer outcomes, including higher mortality rates, increased ICU admissions, and extended hospital stays, and occurs in both people living with diabetes or not. The pre...
Citation: Diabetology & Metabolic Syndrome 2025 17:54 -
Low-density lipoprotein cholesterol predicts coronary artery calcification events in patients with type 2 diabetes: a longitudinal study
Coronary Artery Calcification (CAC) is a major risk factor for various cardiovascular diseases. Low-Density Lipoprotein Cholesterol (LDL-C) is a significant factor in atherosclerotic cardiovascular diseases an...
Citation: Diabetology & Metabolic Syndrome 2025 17:53 -
The prognostic value of remnant cholesterol to adverse renal outcomes in patients with type 2 diabetes
Type 2 diabetes (T2DM) is known to have detrimental effects on renal health. Our study aimed to investigate the relationship between remnant cholesterol (remnant-C) and adverse renal outcomes in patients with ...
Citation: Diabetology & Metabolic Syndrome 2025 17:52 -
Obesity mediates the association between psoriasis and diabetes incidence: a population-based study
The aim of this study was to explore the association between psoriasis and diabetes and to assess the potential moderating role of obesity in this relationship.
Citation: Diabetology & Metabolic Syndrome 2025 17:51 -
The association between visceral fat metabolic score and stroke: mediation by declining kidney function
Stroke is a leading cause of mortality and disability worldwide. Metabolic Score for Visceral Fat (METS-VF), a metric of visceral obesity, has emerged as a novel predictor of metabolic diseases. However, its a...
Citation: Diabetology & Metabolic Syndrome 2025 17:50 -
Metabolic syndrome in type 1 diabetes: higher time above range and glycemic variability revealed by continuous glucose monitoring (CGM)
To investigate the glucose profile of Chinese individuals with type 1 diabetes (T1D) who also have metabolic syndrome.
Citation: Diabetology & Metabolic Syndrome 2025 17:49 -
The combined impact of BMI and ABSI on all-cause mortality among American adults with diabetes
Previous studies have emphasized the independent effects of anthropometric indices—including body mass index (BMI), A Body Shape Index (ABSI), waist-to-height ratio (WHtR), body roundness index (BRI), and Coni...
Citation: Diabetology & Metabolic Syndrome 2025 17:48 -
Causal role of plasma liposome in diabetic retinopathy: mendelian randomization (MR) study
Research indicates that there may be an association between plasma lipidome levels and the incidence of diabetic retinopathy (DR) in patients. However, the potential causality of this relationship is yet to be...
Citation: Diabetology & Metabolic Syndrome 2025 17:47 -
Diabetes and tuberculosis: a systematic review and meta-analyis of mendelian randomization evidence
Tuberculosis (TB) and diabetes mellitus (DM) are global health challenges, each imposing significant morbidity and mortality. Observational studies suggest an increased TB risk in individuals with DM, yet caus...
Citation: Diabetology & Metabolic Syndrome 2025 17:46 -
ZBiotics ameliorates T2DM-induced histopathological damage in liver, kidney and adipose tissues by modulating the NOD-like receptor signaling in Wistar rats
Probiotics serve as promising candidates in type 2 diabetes mellitus (T2DM) therapy. Not only they presumably reduce the T2DM prevalence, but also keep down its complications. In the present study, we explored...
Citation: Diabetology & Metabolic Syndrome 2025 17:45 -
Population characteristics, prescription patterns and glycemic control of users of flash glucose monitoring systems in Brazil: a real-world evidence study
To date, there is a lack of information on the use of flash glucose monitoring system (fCGM) in low-middle income countries, such as Brazil, as well as on digital health platforms most used to calculate the bo...
Citation: Diabetology & Metabolic Syndrome 2025 17:44 -
L-shaped association of body mass index with prognosis in individuals with sepsis: a multicenter cohort study
The relationship between body mass index (BMI) and sepsis prognosis remains highly controversial and uncertain. This study investigated the association between BMI and prognosis in patients with sepsis.
Citation: Diabetology & Metabolic Syndrome 2025 17:43
Annual Journal Metrics
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Citation Impact
Journal Impact Factor: 3.9 (2024)
5-year Journal Impact Factor: 4.3 (2024)
Source Normalized Impact per Paper (SNIP): 1.055 (2024)
SCImago Journal Rank (SJR): 1.152 (2024)Speed
Submission to first editorial decision (median days): 3
Submission to acceptance (median days): 86Usage 2024
Downloads: 1,578,920
Altmetric mentions: 552