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  1. The Cardiovascular-kidney-metabolic (CKM) syndrome is a health disorder caused by interactions between cardiovascular disease, kidney disease, and metabolism-related risk factors. The stress hyperglycemia rati...

    Authors: Fan-Shun Guo, Jia-Hao Dou, Jun-Xiang Wang, Chen Guo, Rui-Yun Wu, Xue-Lu Sun, Yi-Wei Hu and Jin Wei
    Citation: Diabetology & Metabolic Syndrome 2025 17:109
    Content type: Research Published on:

  2. Type 2 diabetes mellitus (T2DM) is closely associated with both environmental and genetic factors, involving multi-gene inheritance. This study examined the association between the polymorphic locus rs10757278...

    Authors: Xinyi Li, Aige Yang, Xiao Liu, Rui Zhang, Huimin Zhou and Shunjiang Xu
    Citation: Diabetology & Metabolic Syndrome 2025 17:108
    Content type: Research Published on:

  3. Fatty pancreas disease (FPD) is characterized by abnormal fat accumulation in pancreatic tissue and is often associated with obesity, metabolic syndrome, and type 2 diabetes mellitus (T2DM). While its pathophy...

    Authors: Tahsin Taner Karaevren, Refika Yorulmaz, Mahinur Cerit, Halit Nahit Şendur, Burak Kalafat, Gizem Yaz Aydın, Özlem Gülbahar, Mehmet Muhittin Yalçın, Ayhan Karakoç, Müjde Aktürk, Füsun Baloş Törüner, Alev Eroğlu Altınova, Taha Enes Çetin and Ethem Turgay Cerit
    Citation: Diabetology & Metabolic Syndrome 2025 17:107
    Content type: Research Published on:

  4. To assess the association between serum uric acid (SUA) level and the prevalence of diabetic retinopathy (DR) and chronic kidney disease (CKD) in patients with long-term diabetes.

    Authors: Hanying Wang, Liping Gu, Yuhang Ma, Xindan Xing, Yuan Qu, Xin Shi, Xinyi Liu, Hancong Wan, Qian Zhu, Yingchen Shen, Chong Chen, Li Su, Yufan Wang and Kun Liu
    Citation: Diabetology & Metabolic Syndrome 2025 17:106
    Content type: Research Published on:

  5. This study aimed to evaluate the associations between neutrophil percentage-to-albumin ratio (NPAR) and both all-cause and cardiovascular mortality in diabetic kidney disease (DKD) patients.

    Authors: Juntao Tan, Jinglong Du, Jiaxiu Liu, Wenlong Zhao and Yanbing Liu
    Citation: Diabetology & Metabolic Syndrome 2025 17:105
    Content type: Research Published on:

  6. Postherpetic neuralgia (PHN) and diabetes mellitus frequently coexist in clinical settings; however, the causal relationship between them remains unclear. Moreover, the potential mediating role of amino acids ...

    Authors: Haoning Lan, Zhangran Ai, Songchao Xu, Huili Li, Zhong Feng, Ruijuan Guo and Yun Wang
    Citation: Diabetology & Metabolic Syndrome 2025 17:104
    Content type: Research Published on:

  7. Type 2 diabetes mellitus (T2DM) is increasingly affecting people aged 15–34, posing a serious public health challenge due to its faster progression and higher complication risks. This study examines the global...

    Authors: Yang Zhou, Yupeng Chen, Yiting Tang, Shan Zhang, Zifan Zhuang and Qing Ni
    Citation: Diabetology & Metabolic Syndrome 2025 17:103
    Content type: Research Published on:

  8. Patients with diabetic nephropathy (DN) often present with lipid profile abnormalities. While associations between these parameters and DN have been suggested, confounding factors obscure causal relationships....

    Authors: Pengfei Xie, Weinan Xie, Zhaobo Wang, Ziwei Guo, Rumeng Tang, Haoyu Yang, Yu Wei, Ling Zhou, Yishan Huang, Linhua Zhao and Lili Zhang
    Citation: Diabetology & Metabolic Syndrome 2025 17:102
    Content type: Research Published on:

  9. we aimed to evaluate the association of interleukin-1β (IL-1β) gene single nucleotide polymorphisms (SNPs) and its interaction with smoking status on diabetic nephropathy (DN) risk in a Chinese Han population.

    Authors: Tianyue Xie and Zhuqi Tang
    Citation: Diabetology & Metabolic Syndrome 2025 17:101
    Content type: Research Published on:

  10. Glycemic variability (GV) is a key determinant of outcomes in critically ill patients, yet its impact on cerebral infarction patients in intensive care units (ICUs) remains underexplored. This study evaluates ...

    Authors: Hui Yang, Hongcai Wang and Yan Jiang
    Citation: Diabetology & Metabolic Syndrome 2025 17:100
    Content type: Research Published on:

  11. The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is a novel lipid indicator used for assessing the risk of cardiovascular diseases. This study was performed to ...

    Authors: Sikun Zhang and Zhaowei Zhu
    Citation: Diabetology & Metabolic Syndrome 2025 17:99
    Content type: Research Published on:

  13. Although studies had shown that Insulin resistance (IR) was correlated with the occurrence of sarcopenia, there were still many controversial conclusions. Therefore, we conducted a more comprehensive study on ...

    Authors: Zikai Jin, Liming Zheng, Chuanrui Sun, Bo Xu, Xiangyun Guo, Yili Zhang, Linghui Li and Xu Wei
    Citation: Diabetology & Metabolic Syndrome 2025 17:97
    Content type: Research Published on:

  14. The triglyceride-glucose (TyG) index, a recognized marker for insulin resistance, holds potential implications for skeletal health. However, its relationship with fragility fractures remains uncertain. We aime...

    Authors: Yuan Lou, Huan Chen, Fuli Man, Lina Zhang and Qi Pan
    Citation: Diabetology & Metabolic Syndrome 2025 17:96
    Content type: Research Published on:

  15. Diabetes retinopathy (DR) is a prevalent microvascular complication of type 2 diabetes mellitus (T2DM). This study investigated the correlation between renal function and DR, as well as the potential mediating...

    Authors: Youran Cai, Wanlu Qiu, Xiao Ma, Yuanting Yang, Ting Tang, Yuying Dong, Jian Chen and Qing Zhou
    Citation: Diabetology & Metabolic Syndrome 2025 17:95
    Content type: Research Published on:

  16. Few studies have evaluated changes in leukocyte telomere length (LTL) over a short time period (e.g. 1 week). LTL shortening is accelerated by exposure to inflammation and reactive oxygen species (ROS) damage.

    Authors: Janet M. Wojcicki, Elissa Epel, Jue Lin, Viva Tai, Jean-Marc Schwarz, Susan M. Noworolski, Ayca Erkin-Cakmak, Kathleen Mulligan, Alejandro Gugliucci and Rob H. Lustig
    Citation: Diabetology & Metabolic Syndrome 2025 17:94
    Content type: Brief Report Published on:

  17. Islet β-cell transplantation offers a promising treatment for repairing pancreatic damage in diabetes, with the transcription factor pancreatic duodenal homeobox-1 (PDX1) being crucial for β-cell function and ...

    Authors: Hui Song, Jiarui Li, Haohao Yang, Bin Kong, Yu Xu, Xiong Li and Hui Li
    Citation: Diabetology & Metabolic Syndrome 2025 17:93
    Content type: Research Published on:

  19. Genetic factors might influence metabolic syndrome (MetS) or any of its components. It was postulated that low density lipoprotein receptor (LDLR) gene variants could play a role in cholesterol hemostasis and the...

    Authors: Hiba S. Al-Amodi, Nazik Altayeb Abdelbasit, Sameer H. Fatani, Mohiuddin M. Taher, Maowia Mohamed Mukhtar, Ayman S. Mohamed, Abdallah M. Gameel, Hala F. M. Kamel and Shimaa Abdelsattar
    Citation: Diabetology & Metabolic Syndrome 2025 17:91
    Content type: Research Published on:

  20. Prediabetes (pre-DM) is recognized as an intermediate state of glucose metabolism with a high potential to progress to diabetes mellitus (DM). However, its prognostic value in patients with premature acute myo...

    Authors: Xinlong Zhao, Yuansong Zhuang, Siqi Tang, Yanping Ruan, Quan Li, Yanbo Liu, Jinyan Lei, Yitao Han, Yuxiong Chen, Yakun Zhao and Zhongjie Fan
    Citation: Diabetology & Metabolic Syndrome 2025 17:90
    Content type: Research Published on:

  21. Diabetic nephropathy (DN) is influenced by dysregulated adipokines, which play a key role in inflammation, immune responses, and lipid metabolism. However, the precise molecular mechanisms linking adipokine dy...

    Authors: Xiaojuan Wang, Mohamad Hafizi Abu Bakar, Mohd Asyraf Kassim, Khairul Anuar Shariff, Jing Wang and Manli Xu
    Citation: Diabetology & Metabolic Syndrome 2025 17:89
    Content type: Research Published on:

  22. Little is known about the relationship between body mass index (BMI) and the prognostic value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients with acute coronary syndrome (ACS). This study...

    Authors: Xiaoquan He, Xiaojing Fang, Jiali Wang, Shumei Zhao, Xiaosong Ding and Hui Chen
    Citation: Diabetology & Metabolic Syndrome 2025 17:88
    Content type: Research Published on:

  23. The hemoglobin glycation index (HGI) represents the difference between the observed and predicted values of haemoglobin A1c (HbA1c). However, the association between HGI and prognosis of heart failure (HF) is ...

    Authors: Ziyu Guo, Yike Li, Shuoyan An and Jingang Zheng
    Citation: Diabetology & Metabolic Syndrome 2025 17:87
    Content type: Research Published on:

  24. This study investigates the gut microbiota components associated with metabolic syndrome in patients living with HIV-1 at Bafoussam Regional Hospital, West Cameroon, it focuses on gastrointestinal mucosal barr...

    Authors: Joël Martial Diesse, Sushama Jadhav, Stephen Lacmata Tamekou, Gustave Simo, Jean Paul Dzoyem, Jacob Souopgui, Jules-Roger Kuiate and Vijay Nema
    Citation: Diabetology & Metabolic Syndrome 2025 17:86
    Content type: Research Published on:

  25. Cardiovascular-Kidney-Metabolic (CKM) syndrome is characterized by the interrelatedness of chronic kidney disease (CKD), cardiovascular disease (CVD), and metabolic disorders. The relationship between estimate...

    Authors: Xiaomin Liang, Kai Lai, Xiaohong Li, Shuiqing Gui, Zemao Xing and Ying Li
    Citation: Diabetology & Metabolic Syndrome 2025 17:85
    Content type: Research Published on:

  26. Diabetes mellitus is associated with systemic damage across multiple organ systems, and an increasing number of patients are presenting with diabetic kidney disease as its initial manifestation. The onset and ...

    Authors: Xinqi Chen, Mingjie Wang and Zhaoli Yan
    Citation: Diabetology & Metabolic Syndrome 2025 17:84
    Content type: Research Published on:

  27. Low-density lipoproteins (LDL) comprise a pool of particles with different densities that may have variable impact on atherogenesis. Studies suggest that obese individuals with elevated body mass index (BMI) a...

    Authors: Eugenio G. Moraes, Giuliano Generoso, Isabela M. Bensenor, Raul D. Santos, Itamar S. Santos, Alessandra C. Goulart, Steven R. Jones, Krishnaji R. Kulkarni, Michael J. Blaha, Peter P. Toth, Paulo A. Lotufo and Marcio Sommer Bittencourt
    Citation: Diabetology & Metabolic Syndrome 2025 17:83
    Content type: Research Published on:

  28. Wolfram syndrome (WS) is a rare autosomal disorder caused by WFS1 gene mutations, currently lacking approved treatments. Preclinical and clinical reports suggest that diabetes medications, such as glucagon-lik...

    Authors: Toomas Jagomäe, Sandra Velling, Tessa Britt Tikva, Varvara Maksimtšuk, Nayana Gaur, Riin Reimets, Allen Kaasik, Eero Vasar and Mario Plaas
    Citation: Diabetology & Metabolic Syndrome 2025 17:82
    Content type: Research Published on:

  29. Left ventricular hypertrophy (LVH), a hallmark of early-stage heart failure (HF), is a common complication in individuals with type 2 diabetes mellitus (T2DM). Metabolic Visceral Fat Score (METS-VF), a novel m...

    Authors: Lu Wang, Simo Liu, Jing Ke, Bin Cao, Di Wang, Qianqian Zhao, Haolin Gong, Yuan Fang, Zhaohui Zheng, Caiguo Yu, Nannan Wu, Yan Ma, Ke Yu, Longyan Yang and Dong Zhao
    Citation: Diabetology & Metabolic Syndrome 2025 17:81
    Content type: Research Published on:

  31. Diabetic peripheral neuropathy (DPN) is a vastly common and bothersome disorder with a clinically challenging course of treatment affecting patients with diabetes. This study aimed to evaluate the efficacy and...

    Authors: Sherien Mohamed Emara, Sarah Farid Fahmy, Mona Mohamed AbdelSalam and Lamia Mohamed El Wakeel
    Citation: Diabetology & Metabolic Syndrome 2025 17:79
    Content type: Research Published on:

  32. Patients with type 2 diabetes (T2D) often experience prolonged periods of asymptomatic hyperglycemia, which significantly increases the risk of developing chronic complications related to diabetes. Screening p...

    Authors: Melanie Rodacki, Lenita Zajdenverg, Wellington Santana da Silva Júnior, Luciano Giacaglia, Carlos Antonio Negrato, Roberta Arnoldi Cobas, Bianca de Almeida-Pititto and Marcello Casaccia Bertoluci
    Citation: Diabetology & Metabolic Syndrome 2025 17:78
    Content type: Research Published on:

  33. Studies have found inconsistent results regarding triglyceride-glucose (TyG) index and bone health. This systematic review aims to synthesize the existing evidence on the association between the (TyG) index, b...

    Authors: Maryam Yousefiasl, Arezou Soltanattar, Ali Ezzatollahi Tanha, Pouria Azami, Maryam Alaei, Amir Ali Alamdari, Farhad Esmailsorkh, Amirhossein Habibzadeh and Shaghayegh Khanmohammadi
    Citation: Diabetology & Metabolic Syndrome 2025 17:77
    Content type: Review Published on:

  34. Diabetic peripheral neuropathy (DPN) is a common complication of type 2 diabetes (T2D). Lipoprotein(a) [Lp(a)], a known cardiovascular risk factor, has been hypothesized to influence the development of DPN. Th...

    Authors: Li Sheng, Yiwen Yang and Yunqing Zhou
    Citation: Diabetology & Metabolic Syndrome 2025 17:76
    Content type: Research Published on:

  35. Abdominal obesity, assessed via the body roundness index (BRI), is a critical determinant of health outcomes. This study explores the association between abdominal obesity and frailty progression across differ...

    Authors: Chong Zhang, Cuijun Hao, Weiru Liang, Kun Hu, Tingting Guo, Yi Chen, Meng Ning and Yingwu Liu
    Citation: Diabetology & Metabolic Syndrome 2025 17:75
    Content type: Research Published on:

  36. Acute kidney injury (AKI) is a common complication that affects the outcomes of patients undergoing percutaneous coronary intervention (PCI). The triglyceride–glucose (TyG) index, a metric computed from fastin...

    Authors: Fan Zhang, Shen Zhan, Lihong Zhang, Xin Zheng, Xiangru Li and Yuzhu Wang
    Citation: Diabetology & Metabolic Syndrome 2025 17:74
    Content type: Research Published on:

  37. Estimated glucose disposal rate (eGDR) is considered as a reliable alternative indicator of insulin resistance. However, the relationship between eGDR levels and mortality among individuals with cardiometaboli...

    Authors: Chao Fu, Yuxin Li, Xiangyang Gao, Yan Gong, Hantong Wang, Guanyun Wang, Xiaoxue Ma, Bingqing Han, Shanshan Liu, Hao Zhang, Fei Wang and Qiang Zeng
    Citation: Diabetology & Metabolic Syndrome 2025 17:73
    Content type: Research Published on:

  38. Metabolic syndrome (MetS) encompasses a collection of metabolic abnormalities. This study aims to determine which combination of MetS components has the highest mortality risk, and to investigate the causal re...

    Authors: Shu Li, Chi Pang Wen, Huakang Tu, Sicong Wang, Xue Li, Andi Xu, Wenyuan Li and Xifeng Wu
    Citation: Diabetology & Metabolic Syndrome 2025 17:72
    Content type: Research Published on:

  39. Pericoronary adipose tissue (PCAT) attenuation, as assessed by coronary computed tomography angiography (CCTA), has been identified as a marker of pericoronary inflammation and a predictor of future adverse at...

    Authors: Tianhao Zhang, Hongkai Zhang, Xuelian Gao, Pingan Peng, Tianlong Chen, Xiaoming Zhang, Jingyao Yang, Yang Zheng, Yulu Peng, Xiaonan Ma, Dongmei Shi, Zhijian Wang, Lei Xu, Yujie Zhou and Yu Du
    Citation: Diabetology & Metabolic Syndrome 2025 17:71
    Content type: Research Published on:

  40. The cluster of cardiovascular risk factors, referred to as metabolic syndrome (MetS), represents a substantial risk factor for cardiovascular diseases and presents a significant public health challenge. Howeve...

    Authors: Cheng-Chieh Lin, Chuan-Wei Yang, Chia-Ing Li, Chiu-Shong Liu, Chih-Hsueh Lin, Shing-Yu Yang and Tsai-Chung Li
    Citation: Diabetology & Metabolic Syndrome 2025 17:70
    Content type: Research Published on:

  41. The stress hyperglycemia ratio (SHR) has recently been suggested to characterize acute glycemic rise better than the admission blood glucose and to be associated with unfavorable outcomes in patients with vari...

    Authors: Tianquan Chen, Yijiao Zhu, Yushuang Liu, Hongxia Li, Zhe Han, Min Liu, Xia Xu and Rong Wang
    Citation: Diabetology & Metabolic Syndrome 2025 17:69
    Content type: Research Published on:

  42. The potential benefits and risks of combination therapy with sodium-glucose co-transporter-2 inhibitors (SGLT-2is) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) versus monotherapy remain a subject o...

    Authors: Asma Mousavi, Shayan Shojaei, Hamidreza Soleimani, Davood Semirani-Nezhad, Pouya Ebrahimi, Ali Zafari, Rasoul Ebrahimi, Khatere Roozbehi, Anil Harrison, Mushabbar A. Syed, Toshiki Kuno, Mani Khorsand Askari, Jaime P. Almandoz, John Jun and Kaveh Hosseini
    Citation: Diabetology & Metabolic Syndrome 2025 17:68
    Content type: Review Published on:

  43. Diabetes prevalence in China is significant, with a large proportion in the prediabetes stage. Dyslipidemia is associated with abnormal glucose metabolism, and the non-high-density lipoprotein cholesterol to h...

    Authors: Sichun Wen, Jingfen Li, Zheng Xie, Xiaohui Chen, Junyi Li and Xiayi Lin
    Citation: Diabetology & Metabolic Syndrome 2025 17:67
    Content type: Research Published on:

    The Correction to this article has been published in Diabetology & Metabolic Syndrome 2025 17:134

  44. Women with prior gestational diabetes mellitus (GDM) are at increased risk of type 2 diabetes, and lifestyle intervention (LSI) offered a decade after pregnancy is effective in preventing diabetes. However, si...

    Authors: Paula Andreghetto Bracco, Angela Jacob Reichelt, Luísia Feichas Alves, Pedro Rodrigues Vidor, Maria Lúcia Rocha Oppermann, Bruce Bartholow Duncan and Maria Inês Schmidt
    Citation: Diabetology & Metabolic Syndrome 2025 17:66
    Content type: Research Published on:

  45. Long-term exposure to air pollution significantly increases the risk of cardiovascular disease (CVD); however, the association and underlying mechanisms in individuals with diabetes remain unconfirmed.

    Authors: Chunyu Yan, Guang Chen, Yingyu Jing, Qi Ruan and Ping Liu
    Citation: Diabetology & Metabolic Syndrome 2025 17:65
    Content type: Research Published on:

  46. Using the method of spectral-probability analysis, to evaluate the possibility of predicting an unfavorable outcome of acute decompensation of diabetes mellitus in patients hospitalized in the intensive care u...

    Authors: L. P. Kogan, K. G. Korneva, A. E. Volvach, S. V. Sorokoumova, A. A. Modelkina and G. A. Novikov
    Citation: Diabetology & Metabolic Syndrome 2025 17:64
    Content type: Research Published on:

  47. Posttraumatic stress disorder (PTSD) patients have a high comorbidity with type 2 diabetes (T2D). Whether PTSD influences the risk of diabetes is still not known. We used GWAS data from European ancestry of PT...

    Authors: Yuqing Song, Ancha Baranova, Hongbao Cao, Weihua Yue and Fuquan Zhang
    Citation: Diabetology & Metabolic Syndrome 2025 17:63
    Content type: Brief Report Published on:

  48. The world-wide prevalence of diabetes distress varies, and studies are mainly undertaken in clinical settings. By using data from the Trøndelag Health (HUNT) study, we aimed to estimate diabetes distress preva...

    Authors: Hilde K.R. Riise, Anne Haugstvedt, Jannicke Igland, Marit Graue, Eirik Søfteland, Monica Hermann, Sofia Carlsson, Timothy C. Skinner, Bjørn Olav Åsvold and Marjolein M. Iversen
    Citation: Diabetology & Metabolic Syndrome 2025 17:62
    Content type: Research Published on:

  49. Plasminogen activator inhibitor-1 (PAI-1) is the main inhibitor of the fibrinolytic system and is mainly secreted from adipose tissue. It is associated with cardiovascular disease and has also been considered ...

    Authors: Jenny Hernestål-Boman, Tina Öhman, Jan-Håkan Jansson, Marcus M. Lind, Olov Rolandsson, Ingvar A. Bergdahl and Lars Johansson
    Citation: Diabetology & Metabolic Syndrome 2025 17:61
    Content type: Research Published on:

  50. Glucagon-like peptide-1 (GLP-1) is an incretin peptide hormone mainly secreted by enteroendocrine intestinal L-cells. GLP-1 is also secreted by α-cells of the pancreas and the central nervous system (CNS). GLP...

    Authors: Maedeh Movahednasab, Hassan Dianat-Moghadam, Sana Khodadad, Reza Nedaeinia, Saeid Safabakhsh, Gordon Ferns and Rasoul Salehi
    Citation: Diabetology & Metabolic Syndrome 2025 17:60
    Content type: Review Published on:

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Diabetology & Metabolic Syndrome

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