Skip to main content

Table 5 Association between α-klotho and all-cause mortality and cardiovascular mortality

From: Association between serum α-klotho levels and the incidence of diabetic kidney disease and mortality in type 2 diabetes: evidence from a Chinese cohort and the NHANES database

 

Model 1

Model 2

Model 3

All-cause mortality

HR

95% CI

p-value

HR

95% CI

p-value

HR

95% CI

p-value

 Q1

reference

reference

reference

 Q2

0.597

0.450–0.791

< 0.001

0.684

0.520–0.901

0.007

0.608

0.402–0.921

0.019

 Q3

0.594

0.448–0.786

< 0.001

0.728

0.552–0.96

0.025

0.646

0.442–0.944

0.024

 Q4

0.676

0.511–0.892

0.006

0.815

0.623–1.066

0.135

0.766

0.518–1.133

0.182

Female

         

 Q1

reference

reference

reference

 Q2

0.537

0.335–0.860

0.010

0.606

0.383–0.958

0.032

0.299

0.160–0.559

< 0.001

 Q3

0.662

0.437–1.003

0.052

0.730

0.488–1.090

0.124

0.466

0.274–0.791

0.005

 Q4

0.766

0.509–1.153

0.202

0.865

0.584–1.282

0.470

0.695

0.384–1.259

0.230

Male

         

 Q1

reference

reference

reference

 Q2

0.643

0.451–0.918

0.015

0.739

0.522–1.048

0.090

0.874

0.5126–1.491

0.622

 Q3

0.548

0.374–0.803

0.002

0.708

0.483–1.037

0.076

0.844

0.515–1.382

0.500

 Q4

0.616

0.421-0.900

0.012

0.762

0.526–1.103

0.150

0.913

0.525–1.586

0.747

Cardiovascular mortality

         

 Q1

reference

reference

reference

 Q2

0.492

0.306–0.79

0.003

0.574

0.362–0.91

0.018

0.643

0.326–1.267

0.202

 Q3

0.514

0.331–0.798

0.003

0.653

0.424–1.004

0.052

0.715

0.369–1.387

0.321

 Q4

0.553

0.35–0.873

0.011

0.671

0.428–1.052

0.082

0.923

0.440–1.933

0.831

Female

         

 Q1

reference

reference

reference

 Q2

0.660

0.309–1.409

0.283

0.761

0.365–1.589

0.467

0.299

0.160–0.559

< 0.001

 Q3

0.57

0.297–1.093

0.091

0.649

0.343–1.228

0.184

0.466

0.274–0.791

0.005

 Q4

0.588

0.298–1.16

0.126

0.657

0.337–1.281

0.218

0.695

0.384–1.259

0.230

Male

         

 Q1

reference

reference

reference

 Q2

0.386

0.217–0.685

0.001

0.454

0.006–1.589

0.006

0.752

0.292–1.932

0.553

 Q3

0.484

0.265–0.882

0.018

0.658

0.156–1.228

0.156

1.247

0.530–2.937

0.613

 Q4

0.543

0.293–1.007

0.053

0.69

0.225–1.281

0.225

1.713

0.633–4.635

0.289

  1. CI, confidence interval. Model 1 is unadjusted; Model 2 is adjusted for gender, age, and race; Model 3 is further adjusted for education, marital status, PIR, BMI, drinking status, smoking status, hypertension, CVD, LDL, HDL, TG, TC and UA
Back to article page

Diabetology & Metabolic Syndrome

ISSN: 1758-5996

Contact us