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Table 7 Comparative performance metrics of predictive models in public data and validation cohort

From: DNA methylation patterns and predictive models for metabolic disease risk in offspring of gestational diabetes mellitus

Performance metric

Public data (n = 1,000)

Validation cohort (n = 10)

AUC (95% CI)

0.89 (0.87–0.91)

0.82 (0.72–0.92)

Sensitivity

88%

85%

Specificity

90%

83%

Accuracy

89%

84%

Positive predictive value

89%

83%

Negative predictive value

89%

85%

F1 score

0.885

0.840

Brier score

0.072

0.135