Table 1 Summary of significant plasma proteins from mediation MR analysis of causal metabolites on DR outcomes
Exposure | Mediate proteins | Outcome | Total Effect | Effect of Exposure on Mediator | Effect of Mediator on Outcome | Mediation Effect | Proportion Mediated | Direct Effect | P-value |
|---|---|---|---|---|---|---|---|---|---|
Triglycerides in large LDL | BCAM | DR | -0.119 | -0.194 | 0.122 | -0.024 | 0.198 | -0.096 | 1.39E-02 |
Triglycerides in large LDL | TMEM2 | DR | -0.119 | -0.122 | -0.123 | 0.015 | -0.126 | -0.134 | 3.47E-02 |
Triglycerides in large LDL | SVEP1 | DR | -0.119 | -0.117 | 0.087 | -0.01 | 0.085 | -0.109 | 4.26E-02 |
Concentration of very small VLDL particles | ST4S6 | DR | -0.136 | -0.188 | -0.16 | 0.03 | -0.221 | -0.166 | 6.46E-03 |
Concentration of very small VLDL particles | CLIC5 | DR | -0.136 | -0.22 | 0.287 | -0.063 | 0.464 | -0.073 | 3.07E-03 |
Concentration of very small VLDL particles | BCAM | DR | -0.136 | -0.129 | 0.122 | -0.016 | 0.116 | -0.12 | 4.24E-02 |
Concentration of very small VLDL particles | DKK3 | DR | -0.136 | -0.122 | -0.11 | 0.013 | -0.099 | -0.15 | 4.80E-02 |
Phospholipids in very small VLDL | N- terminal pro-BNP | DR | -0.126 | -0.128 | -0.123 | 0.016 | -0.125 | -0.142 | 3.02E-02 |
Phospholipids in very small VLDL | ST4S6 | DR | -0.126 | -0.17 | -0.16 | 0.027 | -0.215 | -0.153 | 8.58E-03 |
Phospholipids in very small VLDL | CLIC5 | DR | -0.126 | -0.207 | 0.287 | -0.059 | 0.469 | -0.067 | 4.96E-03 |
Phospholipids in very small VLDL | DKK3 | DR | -0.126 | -0.138 | -0.11 | 0.015 | -0.121 | -0.142 | 3.20E-02 |
Triglycerides in LDL | BCAM | DR | -0.108 | -0.186 | 0.122 | -0.023 | 0.211 | -0.085 | 1.87E-02 |
Triglycerides in LDL | SVEP1 | DR | -0.108 | -0.144 | 0.089 | -0.013 | 0.119 | -0.095 | 3.80E-02 |
Free cholesterol in very small VLDL | BCAM | DR | -0.147 | -0.13 | 0.122 | -0.016 | 0.108 | -0.131 | 4.49E-02 |
Free cholesterol in very small VLDL | PGRC2 | DR | -0.147 | -0.093 | -0.173 | 0.016 | -0.11 | -0.163 | 1.76E-02 |
Total lipids in very small VLDL | ST4S6 | DR | -0.134 | -0.17 | -0.146 | 0.025 | -0.185 | -0.158 | 1.01E-02 |
Total lipids in very small VLDL | THTR | DR | -0.134 | -0.08 | -0.085 | 0.007 | -0.051 | -0.14 | 4.59E-02 |
Total lipids in very small VLDL | BCAM | DR | -0.134 | -0.161 | 0.122 | -0.02 | 0.147 | -0.114 | 2.27E-02 |
Total lipids in very small VLDL | CLIC5 | DR | -0.134 | -0.214 | 0.287 | -0.061 | 0.458 | -0.072 | 4.06E-03 |
Total lipids in very small VLDL | SIRPG | DR | -0.134 | 0.133 | 0.212 | 0.028 | -0.211 | -0.162 | 2.91E-02 |
Total lipids in very small VLDL | DKK3 | DR | -0.134 | -0.129 | -0.11 | 0.014 | -0.106 | -0.148 | 3.79E-02 |
Cholesteryl esters in very small VLDL | ST4S6 | DR | -0.109 | -0.12 | -0.146 | 0.018 | -0.162 | -0.126 | 3.46E-02 |
Cholesteryl esters in very small VLDL | SIRPG | DR | -0.109 | 0.14 | 0.212 | 0.03 | -0.273 | -0.138 | 2.38E-02 |
Cholesteryl esters in very small VLDL | CLIC5 | DR | -0.109 | -0.196 | 0.287 | -0.056 | 0.516 | -0.053 | 7.50E-03 |
Phospholipids to total lipids ratio in large LDL | NAD(P)H dehydrogenase | Background DR | 0.135 | 0.099 | 0.14 | 0.014 | 0.103 | 0.121 | 1.68E-02 |
Polyunsaturated fatty acids | RFNG | PDR | -0.118 | 0.382 | 0.194 | 0.074 | -0.63 | -0.192 | 1.80E-03 |
Polyunsaturated fatty acids | PDE4D | PDR | -0.118 | 0.107 | -0.234 | -0.025 | 0.212 | -0.093 | 3.55E-02 |
Total cholines | RFNG | PDR | -0.107 | 0.312 | 0.194 | 0.061 | -0.564 | -0.168 | 8.24E-03 |