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Fig. 2 | Diabetology & Metabolic Syndrome

Fig. 2

From: Causal roles of lipids and mediating proteins in diabetic retinopathy: insights from metabolomic and proteomic Mendelian randomization

Fig. 2

Proteins mediating the causal effect of triglycerides on DR. The chord diagram illustrated that ten proteins significantly mediated the causal effect of triglycerides on diabetic retinopathy(DR). A. Protein-protein interaction (PPI) analysis revealed that among these ten proteins, only Proto-Oncogene, Src Family Tyrosine Kinase (FYN), and Neogenin 1 (NEO1) exhibited interactions. C. Enrichment analyses demonstrated that Retinol Dehydrogenase 16 (RDH16), Dickkopf-related protein 3 (DKK3), NEO1, and FYN were significantly implicated in various biological processes, including Cellular Hormone Metabolic Process (GO: BP), Cellular Response to Transforming Growth Factor Beta Stimulus (GO: BP), Threonine Kinase Signaling Pathway (GO: BP), Postsynaptic Density (GO: CC), Co-receptor Binding (GO: MF), Axon Guidance (KEGG), and Retinol Metabolism (KEGG) (Fig. 2C, adjusted P < 0.05)

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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