Association between estimated glucose disposal rate and future cardiovascular disease risk across glucose metabolism status: a prospective cohort study

Liang, Xiaomin; Lai, Kai; Li, Xiaohong; Ren, Di; Gui, Shuiqing; Xing, Zemao; Li, Ying

doi:10.1186/s13098-025-01697-6

Table 2 Relationship between eGDR and CVD risk across different glucose metabolism status

From: Association between estimated glucose disposal rate and future cardiovascular disease risk across glucose metabolism status: a prospective cohort study

Exposure	Non-adjusted HR (95% CI) P value	Adjust I HR (95% CI) P value	Adjust II HR (95% CI) P value
Normoglycemia
eGDR (mg/kg/min)	0.86 (0.83, 0.89) < 0.0001	0.87 (0.84, 0.90) < 0.0001	0.87 (0.84, 0.90) < 0.0001
eGDR quartile (mg/kg/min)
Q1	1.0	1.0	1.0
Q2	0.76 (0.62, 0.94) 0.0090	0.77 (0.63, 0.94) 0.0115	0.78 (0.63, 0.95) 0.0152
Q3	0.56 (0.46, 0.69) < 0.0001	0.59 (0.48, 0.73) < 0.0001	0.59 (0.48, 0.73) < 0.0001
Q4	0.44 (0.36, 0.54) < 0.0001	0.46 (0.37, 0.57) < 0.0001	0.46 (0.37, 0.57) < 0.0001
P for trend	< 0.0001	< 0.0001	< 0.0001
Prediabetes
eGDR (mg/kg/min)	0.90 (0.87, 0.93) < 0.0001	0.92 (0.89, 0.95) < 0.0001	0.92 (0.89, 0.95) < 0.0001
eGDR quartile (mg/kg/min)
Q1	1.0	1.0	1.0
Q2	0.74 (0.62, 0.88) 0.0006	0.78 (0.65, 0.92) 0.0043	0.77 (0.65, 0.92) 0.0036
Q3	0.59 (0.49, 0.71) < 0.0001	0.66 (0.54, 0.79) < 0.0001	0.66 (0.55, 0.80) < 0.0001
Q4	0.60 (0.49, 0.73) < 0.0001	0.65 (0.53, 0.79) < 0.0001	0.65 (0.53, 0.80) < 0.0001
P for trend	< 0.0001	< 0.0001	< 0.0001
Diabetes
eGDR (mg/kg/min)	0.85 (0.81, 0.89) < 0.0001	0.85 (0.81, 0.89) < 0.0001	0.88 (0.83, 0.92) < 0.0001
eGDR quartile (mg/kg/min)
Q1	1.0	1.0	1.0
Q2	0.54 (0.42, 0.69) < 0.0001	0.54 (0.42, 0.70) < 0.0001	0.58 (0.44, 0.75) < 0.0001
Q3	0.43 (0.30, 0.61) < 0.0001	0.44 (0.31, 0.63) < 0.0001	0.50 (0.35, 0.73) 0.0002
Q4	0.34 (0.22, 0.51) < 0.0001	0.35 (0.23, 0.53) < 0.0001	0.43 (0.28, 0.68) 0.0003
P for trend	< 0.0001	< 0.0001	< 0.0001
Total
eGDR (mg/kg/min)	0.88 (0.86, 0.89) < 0.0001	0.89 (0.87, 0.90) < 0.0001	0.89 (0.87, 0.91) < 0.0001
eGDR quartile (mg/kg/min)
Q1	1.0	1.0	1.0
Q2	0.70 (0.62, 0.78) < 0.0001	0.71 (0.64, 0.80) < 0.0001	0.72 (0.64, 0.81) < 0.0001
Q3	0.55 (0.48, 0.62) < 0.0001	0.59 (0.52, 0.67) < 0.0001	0.59 (0.52, 0.67) < 0.0001
Q4	0.48 (0.42, 0.54) < 0.0001	0.51 (0.44, 0.58) < 0.0001	0.52 (0.45, 0.59) < 0.0001
P for trend	< 0.0001	< 0.0001	< 0.0001

Non-adjusted model was conducted without adjustment
Adjust I model was adjusted for gender and age
Adjust II model was adjusted for gender, age, living place, education level, marital status, drinking status, smoking status, CRP, WBC, platelets, FPG, BUN, Scr, UA, TG, HDL-c, LDL-c, BMI

Back to article page

ISSN: 1758-5996

Contact us

Submission enquiries: journalsubmissions@springernature.com

Diabetology & Metabolic Syndrome

Contact us