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Table 2 Cox regression analysis of SDOH and long-term mortality in MetS participants

From: Association between social determinants of health with the all-cause and cause-specific (cancer and cardio-cerebrovascular) mortality among the population with metabolic syndrome: NHANES 2005–2018

 

Crude model

Model 1

Model 2

All-cause mortality

HR (95%CI)

P

HR (95%CI)

P

HR (95%CI)

P

Q1

ref

 

ref

 

ref

 

Q2

1.77(1.46,2.16)

< 0.0001

1.51(1.27,1.80)

< 0.0001

1.55(1.30,1.84)

< 0.0001

Q3

1.74(1.36,2.22)

< 0.0001

2.08(1.67,2.58)

< 0.0001

1.98(1.59,2.46)

< 0.0001

Q4

1.56(1.22,1.99)

< 0.001

2.51(1.96,3.23)

< 0.0001

2.41(1.87,3.12)

< 0.0001

P for trend

 

< 0.0001

 

< 0.0001

 

< 0.0001

Cancer mortality

      

Q1

ref

 

ref

 

ref

 

Q2

1.43(1.02,2.00)

0.04

1.35(0.97,1.88)

0.08

1.45(1.05,1.99)

0.02

Q3

1.82(1.14,2.89)

0.01

2.38(1.49,3.82)

< 0.001

2.51(1.57,4.02)

< 0.001

Q4

1.17(0.76,1.81)

0.47

2.18(1.38,3.45)

< 0.001

2.45(1.54,3.89)

< 0.001

P for trend

 

0.11

 

< 0.0001

 

< 0.0001

Cardio − cerebrovascular disease mortality

      

Q1

ref

 

ref

 

ref

 

Q2

2.25(1.67,3.03)

< 0.0001

1.97(1.46,2.64)

< 0.0001

1.98(1.47,2.66)

< 0.0001

Q3

1.52(1.02,2.27)

0.04

2.05(1.41,2.98)

< 0.001

1.78(1.22,2.61)

0.003

Q4

1.54(1.04,2.27)

0.03

2.89(1.96,4.25)

< 0.0001

2.62(1.79,3.84)

< 0.0001

P for trend

 

0.01

 

< 0.0001

 

< 0.0001

  1. Crude model: No adjustment for any potential influence factors
  2. Model 1: Adjusted for age, sex, ethnicity, alcohol user, smoke, BMI
  3. Model 2: Adjusted for age, sex, ethnicity, alcohol user, smoke, BMI, DM, Hypertension, CCVD, Hyperlipidemia, cancer, depression
  4. Abbreviations: HR, hazard ratio; CI, confidence interval; BMI, body mass index; DM, diabetes mellitus; CCVD, cardio-cerebral vascular disease; SDOH, Social determinants of health