Table 5 The associations of F/M with thyroid hormone sensitivity in gender subgroup

Female

Model I

One-line effect

 − 0.03 (− 0.07, 0.02) 0.2375

0.51 (0.12, 0.89) 0.0101

8.85 (− 3.15, 20.85) 0.1491

0.51 (− 0.01, 1.03) 0.0532

Model II

Inflection point (k)

0.4

0.32

0.76

0.76

 < K segment effect 1

 − 0.09 (− 0.21, 0.02) 0.1084

 − 0.54 (− 2.24, 1.16) 0.5326

10.81 (− 2.09, 23.71) 0.1015

0.62 (0.06, 1.17) 0.0311

 > K segment effect 2

 − 0.01 (− 0.06, 0.05) 0.7711

0.63 (0.20, 1.06) 0.0043

 − 5.04 (− 40.65, 30.58) 0.7817

 − 0.21 (− 1.75, 1.33) 0.7876

Effect difference

0.09 (− 0.05, 0.22) 0.2131

1.17 (− 0.67, 3.02) 0.2136

 − 15.85 (− 54.09, 22.40) 0.4173

 − 0.83 (− 2.48, 0.83) 0.3273

The predicted value of the equation at the inflection point

0.33 (0.32, 0.34)

 − 0.10 (− 0.17, − 0.04)

28.25 (25.73, 30.78)

2.42 (2.31, 2.53)

Log-likelihood ratio test

0.207

0.207

0.411

0.321

Male

Model I

One-line effect

 − 0.04 (− 0.08, 0.01) 0.1269

0.49 (0.12, 0.85) 0.0088

7.29 (− 3.50, 18.07) 0.1861

0.50 (0.02, 0.99) 0.0419

Model II

Inflection Point (k)

0.2

0.57

0.58

0.58

 < K segment effect 1

0.14 (− 0.11, 0.40) 0.2596

0.85 (0.41, 1.29) 0.0002

14.87 (1.92, 27.83) 0.0249

0.92 (0.34, 1.50) 0.0019

 > K segment effect 2

 − 0.05 (− 0.10, − 0.00) 0.0455

 − 0.85 (− 1.83, 0.13) 0.0897

 − 22.30 (− 52.49, 7.88) 0.1482

 − 1.14 (− 2.48, 0.21) 0.0992

Effect difference

 − 0.20 (− 0.47, 0.07) 0.1531

 − 1.70 (− 2.86, − 0.54) 0.0042

 − 37.18 (− 72.61, − 1.74) 0.0403

 − 2.06 (− 3.64, − 0.48) 0.0111

The predicted value of the equation at the inflection point

0.35 (0.34, 0.36)

0.08 (0.01, 0.15)

24.46 (22.33, 26.58)

2.31 (2.22, 2.41)

Log-likelihood ratio test

0.148

0.004

0.038

0.01