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Table 2 The associations between hs-CRP/HDL-C ratio and risk markers of T2D

From: Non-linear association of a novel inflammation-lipid composite marker CRP/HDL with insulin resistance and type 2 diabetes: findings from a comprehensive national cross-sectional study

Outcomes

β (95% CI)

(hs-CRP/HDL-C)*10

Q1

Q2

Q3

Q4

P for trend

FPG

      

Model1

2.6(1.7, 3.5)

Reference

4.9(3.0, 6.9)

11.0(7.3,14.0)

16.0(14.0, 19.0)

< 0.001

Model2

2.5(1.7, 3.3)

Reference

2.0(0.33, 3.7)

8.1(5.1,11.0)

15.0(12.0,17.0)

< 0.001

Model3

2.6(1.8, 3.4)

Reference

0.26(-1.6, 2.2)

5.2(2.0, 8.5)

9.6(5.8, 13.0)

< 0.001

HBA1C

      

Model1

0.10(0.07, 0.13)

Reference

0.15(0.09,0.21)

0.33(0.24, 0.43)

0.56(0.48, 0.65)

< 0.001

Model2

0.09(0.06, 0.11)

Reference

0.05(0.00, 0.10)

0.24(0.15, 0.32)

0.47(0.40, 0.54)

< 0.001

Model3

0.09(0.06, 0.11)

Reference

0.00(-0.06, 0.06)

0.15(0.06, 0.24)

0.31(0.21, 0.41)

< 0.001

FSI

      

Model1

1.9(1.1, 2.6)

Reference

2.3(1.3, 3.4)

6.4(5.0, 7.9)

13.0(11.0, 14.0)

< 0.001

Model2

1.8(1.1, 2.6)

Reference

1.9(0.85, 2.9)

6.0(4.5, 7.5)

12.0(11.0, 14.0)

< 0.001

Model3

1.5(0.77, 2.3)

Reference

-0.62(-1.7, 0.47)

1.5(-0.26, 3.2)

4.3(2.8, 5.9)

< 0.001

HOMA-IR

      

Model1

0.61(0.35, 0.88)

Reference

0.59(0.29, 0.89)

1.9(1.4, 2.3)

3.8(3.3, 4.3)

< 0.001

Model2

0.59(0.33, 0.85)

Reference

0.38(0.09, 0.68)

1.7(1.2, 2.1)

3.6(3.1, 4.1)

< 0.001

Model3

0.51(0.24, 0.78)

Reference

-0.3(-0.62, 0.01)

0.44(-0.10, 0.97)

1.5(0.79, 2.1)

< 0.001

  1. Model1: Non-adjusted
  2. Model2: adjusted for age, gender, race, education level, and PIR ratio
  3. Model3: included additional adjustments for hypertension, BMI, smoking status, alcohol consumption, TC, ALT, γ-GGT, SCr, SUA, and Hb
  4. Abbreviations: OR: Odds Ratio; CI: confidence interval; T2D type 2 diabetes, BMI body mass index, PIR family income to poverty, FPG fasting plasma glucose, HbA1c glycosylated hemoglobin, FSI fasting serum insulin, HOMA-IR homeostasis model assessment of insulin resistance, TC total cholesterol, ALT alanine aminotransferase, γ-GGT gamma-glutamyl transpeptidase, SCr serum creatinine, SUA serum uric acid, Hb Hemoglobin