Table 5 Sensitivity analysis for stratified Cox regression for the association of Statins use and risk of incident diabetes in participants without pre-diabetes (no Statins use as the reference, HR, 95%CI, P)
Crude model | Model 1 | Model 2 | Model 3 | |
|---|---|---|---|---|
Men participants | ||||
Intermittent use vs. no use | 0.91 (0.69,1.19), 0.481 | 0.86 (0.66,1.14), 0.291 | 0.84 (0.63,1.11), 0.216 | 0.85 (0.64,1.13), 0.257 |
Persistent use vs. no use | 1.78 (1.27,2.50), 0.001 | 1.66 (1.18,2.34), 0.004 | 1.64 (1.15,2.34), 0.006 | 1.69 (1.17,2.44), 0.006 |
women participants | ||||
Intermittent use vs. no use | 0.96 (0.62,1.50), 0.865 | 0.86 (0.54,1.35), 0.499 | 0.98 (0.62,1.58), 0.944 | 1.03 (0.63,1.70), 0.894 |
Persistent use vs. no use | 1.42 (0.82,2.45), 0.213 | 1.26 (0.72,2.19), 0.420 | 1.51 (0.84,2.71), 0.165 | 1.61 (0.87,2.96), 0.129 |
age groups < 45years | ||||
Intermittent use vs. no use | 1.11 (0.79,1.54), 0.548 | 1.04 (0.74,1.45), 0.824 | 1.00 (0.71,1.41), 0.981 | 1.23 (0.73,1.46), 0.878 |
Persistent use vs. no use | 1.92 (1.07,3.44), 0.028 | 2.08 (1.16,3.73), 0.014 | 2.08 (1.14,3.82), 0.018 | 2.15 (1.15,4.01), 0.016 |
45-60years | ||||
Intermittent use vs. no use | 0.70 (0.49,0.99), 0.046 | 0.64 (0.45,0.91), 0.014 | 0.64 (0.45,0.92), 0.017 | 0.65 (0.45,0.94), 0.023 |
Persistent use vs. no use | 1.59 (1.05,2.40), 0.030 | 1.42 (0.94,2.16), 0.097 | 1.45 (0.95,2.22), 0.088 | 1.51 (0.98,2.31), 0.062 |
≥ 60years | ||||
Intermittent use vs. no use | 1.08 (0.34,3.43), 0.897 | 1.35 (0.33,5.53), 0.675 | 1.58 (0.33,7.69), 0.570 | 1.54 (0.32,7.50), 0.594 |
Persistent use vs. no use | 1.26 (0.38,4.16), 0.709 | 1.52 (0.36,6.42), 0.572 | 1.59 (0.32,7.85), 0.570 | 1.54 (0.31,7.63), 0.596 |
Non-obese participants | ||||
Intermittent use vs. no use | 0.71 (0.28,1.78), 0.463 | 0.66 (0.26,1.66), 0.381 | 0.58 (0.22,1.52), 0.267 | 0.51 (0.19,1.40), 0.192 |
Persistent use vs. no use | 1.26 (0.41,3.91), 0.691 | 1.26 (0.40,3.92), 0.692 | 1.01 (0.30,3.41), 0.983 | 0.96 (0.27,3.42), 0.946 |
Obese participants | ||||
Intermittent use vs. no use | 0.92 (0.72,1.17), 0.493 | 0.85 (0.67,1.09), 0.201 | 0.84 (0.65,1.08), 0.170 | 0.86 (0.67,1.11), 0.254 |
Persistent use vs. no use | 1.70 (1.25,2.30), 0.001 | 1.51 (1.11,2.05), 0.009 | 1.53 (1.12,2.10), 0.007 | 1.60 (1.16,2.22), 0.005 |
OSA severity groups, mild | ||||
Intermittent use vs. no use | 1.08 (0.74,1.57), 0.708 | 1.03 (0.70,1.51), 0.884 | 1.08 (0.73,1.59), 0.701 | 1.07 (0.72,1.59), 0.747 |
Persistent use vs. no use | 1.72 (1.04,2.84), 0.034 | 1.61 (0.97,2.66), 0.064 | 1.72 (1.03,2.88), 0.039 | 1.65 (0.97,2.84), 0.066 |
Moderate + severe | ||||
Intermittent use vs. no use | 0.87 (0.64,1.19), 0.387 | 0.79 (0.58,1.08), 0.142 | 0.77 (0.56,1.07), 0.115 | 0.82 (0.59,1.14), 0.233 |
Persistent use vs. no use | 1.55 (1.06,2.27), 0.025 | 1.40 (0.96,2.06), 0.084 | 1.40 (0.94,2.09), 0.098 | 1.53 (1.01,2.32), 0.047 |