Table 1 The roles of Plin5 in diabetes-related target organs
From: Plin5: A potential therapeutic target for type 2 diabetes mellitus
| Â | Plin5 status | pathway | changed | Reference |
|---|---|---|---|---|
Fat | Plin5 phosphorylation | Cold stimulates lipolysis↑ | Browning of white fat cells↑ | |
skeletal muscle | Plin5 expression | Lipid droplet decomposition and synthesis | insulin sensitivity↑ | [67] |
liver | Plin5 deficiency | JNK-p38-ATF pathway | Impaired insulin signal transduction↑ | |
pancreas | Plin5 overexpression | PI3K/Akt pathway↑, ERK pathway↑ | apoptosis↓, oxidative stress↓, Lipotoxicity of β-cells↓ | |
heart | MHC-Plin5 mice | Plin5 interacted with SERCA2↑, calcium treatment↑ | Myocyte contractility↑, Left ventricular mass and myocardial cell size↑, Heart function is preserved | [71] |
sertoli cell | Plin5 overexpression | Akt/GSK-3β/ NRF2 pathway↑ | Apoptosis↓, Oxidative stress and inflammation↓, sertoli cell injury↓ | [72] |
blood vessel | ApoE(−/−)Plin5(-/-) | PI3K/AKT and MAPKs pathway↑, NF-κB pathway↑ | Oxidative stress and inflammation↑, Lesion of capillary structure and function↑ |