Fig. 1
From: White adipose tissue in type 2 diabetes and the effect of antidiabetic drugs
Interactions between T2D and WAT. T2D causes changes in WAT distribution and metabolism, adipocyte hypertrophy, WAT inflammation, lipotoxicity, WAT aging, and dysregulation of adipokines. These pathological changes may further contribute to the progression of insulin resistance and T2D. Abbreviation: WAT: white adipose tissue; SAT: subcutaneous adipose tissue; VAT: visceral adipose tissue; IMAT: intermuscular adipose tissue; ASCs: adipose tissue-derived mesenchymal stem cells; APCs: adipocyte progenitor cells; PAI-1: plasminogen activator inhibitor-1; ZMAT3: zinc finger matrin-type 3; FFAs: free fatty acids