Association of the interaction between interleukin-1β gene polymorphism and smoking status with the diabetic nephropathy risk in a Chinese Han population

Table 4 GMDR analysis on the best SNP–SNP and gene- smoking status interaction models

Locus no.	Best combination	Cross-validation consistency	Training balanced accuracy	Testing balanced accuracy	p-values ^*
SNP- SNP interactions *
2	rs16944, rs3917356	7/10	0.6523	0.4785	0.32
3	rs16944, rs3917356, rs1143634	8/10	0.6353	0.4874	0.62
4	rs16944, rs3917356, rs1143634, rs1143627	6/10	0.5664	0.4956	0.88
Gene- smoking interactions **
2	rs16944, smoking	10/10	0.7688	0.5721	0.011
3	rs16944, rs3917356, smoking	8/10	0.7129	0.4956	0.26
4	rs16944, rs3917356, rs1143634, smoking	5/10	0.5268	0.4785	0.76
5	rs16944, rs3917356, rs1143634, rs1143627, smoking	6/10	0.5664	0.4852	0.81

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