Table 4 Odds ratios of metabolic syndrome for predictive sleep duration, and predictive likelihood of long sleep and short sleep derived from unweighted and weighted GRS

Variables

n

Yes, n (%)

Crude model

Adjusted model

Estimated sleep duration derived from unweighted GRS

Per 1 standard deviation

0.64 (0.63, 0.66)***

0.64 (0.62, 0.66)***

Q1: <6.54399

8317

3087 (37.12)

1.00

1.00

Q2: 6.54399–6.60197

8318

2179 (26.20)

0.60 (0.56, 0.64)***

0.60 (0.56, 0.64)***

Q3: 6.60198–6.65653

8317

1647 (19.80)

0.42 (0.39, 0.45)***

0.42 (0.39, 0.45)***

Q4: ≥6. 65,654

8318

1285 (15.45)

0.31 (0.29, 0.33)***

0.31 (0.28, 0.33)***

Estimated sleep duration derived from weighted GRS

Per 1 standard deviation

0.65 (0.63, 0.66)***

0.64 (0.63, 0.66)***

Q1: <6.54214

8317

3064 (36.84)

1.00

1.00

Q2: 6.54214–6.60172

8318

2178 (26.18)

0.61 (0.57, 0.65)***

0.60 (0.56, 0.65)***

Q3: 6.60173–6.65765

8317

1644 (19.77)

0.42 (0.39, 0.45)***

0.42 (0.39, 0.45)***

Q4: ≥6.65766

8318

1312 (15.77)

0.32 (0.30, 0.35)***

0.32 (0.29, 0.34)***

Phat of long sleep derived from unweighted GRS

Per 1 standard deviation

1.55 (1.51, 1.59)***

1.55 (1.51, 1.59)***

Q1: <0.00487

8317

1228 (14.76)

1.00

1.00

Q2: 0.00487–0.00846

8318

1680 (20.20)

1.46 (1.35, 1.58)***

1.46 (1.35, 1.59)***

Q3: 0.00847–0.01259

8317

2238 (26.91)

2.13 (1.97, 2.30)***

2.14 (1.98, 2.31)***

Q4: ≥0.01260

8318

3052 (36.69)

3.35 (3.10, 3.61)***

3.37 (3.12, 3.64)***

Phat of long sleep derived from weighted GRS

Per 1 standard deviation

1.55 (1.51, 1.59)***

1.55 (1.51, 1.59)***

Q1: <0.00488

8318

1252 (15.05)

1.00

1.00

Q2: 0.00488–0.00848

8317

1651 (19.85)

1.40 (1.29, 1.52)***

1.41 (1.30, 1.53)***

Q3: 0.00849–0.01260

8318

2232 (26.83)

2.07 (1.92, 2.24)***

2.08 (1.93, 2.25)***

Q4: ≥0.01261

8317

3063 (36.83)

3.29 (3.05, 3.55)***

3.32 (3.07, 3.58)***

Phat of short sleep derived from unweighted GRS

Per 1 standard deviation

1.65 (1.61, 1.69)***

1.66 (1.62, 1.70)***

Q1: <0.02208

8318

1071 (12.88)

1.00

1.00

Q2: 0.02208–0.03063

8317

1631 (19.61)

1.65 (1.52, 1.80)***

1.65 (1.52, 1.80)***

Q3: 0.03064–0.03983

8318

2261 (27.18)

2.53 (2.33, 2.74)***

2.54 (2.34, 2.75)***

Q4: ≥0.03984

8317

3235 (38.90)

4.31 (3.99, 4.66)***

4.38 (4.04, 4.74)***

Phat of short sleep derived from weighted GRS

Per 1 standard deviation

1.65 (1.61, 1.69)***

1.66 (1.61, 1.70)***

Q1: <0.02200

8318

1056 (12.70)

1.00

1.00

Q2: 0.02200–0.03059

8317

1671 (20.09)

1.73 (1.59, 1.88)***

1.73 (1.59, 1.89)***

Q3: 0.03060–0.03994

8318

2271 (27.30)

2.58 (2.38, 2.80)***

2.60 (2.40, 2.83)***

Q4: ≥0.03995

8317

3200 (38.48)

4.30 (3.98, 4.65)***

4.36 (4.03, 4.73)***