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Table 3 Odds ratios of metabolic syndrome with unweighted and weighted GRSs for sleep duration, and long and short sleep duration (genetic risk score level of MR assumption 3)

From: Causal relationship of sleep duration on risks for metabolic syndrome: a Mendelian randomization study

  

Metabolic syndrome OR (95% CI)

Variables

n

Yes, n (%)

Crude model

Adjusted model

Unweighted GRS for sleep duration related SNPs†

0.99 (0.97, 1.01)

0.97 (0.95, 1.00)

 Q1: < 6

6182

1515 (24.51)

1.00

1.00

 Q2: 6–7

8187

2056 (25.11)

1.03 (0.96, 1.12)

1.02 (0.94, 1.12)

 Q3: 8–9

8795

2160 (24.56)

1.00 (0.93, 1.08)

0.97 (0.89, 1.06)

 Q4: >9

10,106

2467 (24.41)

1.00 (0.92, 1.07)

0.96 (0.88, 1.05)

Unweighted GRS for long sleep related SNPs†

1.02 (0.99, 1.04)

1.02 (0.99, 1.04)

 Q1: < 2

5675

1384 (24.39)

1.00

1.00

 Q2: 2

23,096

5674 (24.57)

1.01 (0.94, 1.08)

1.01 (0.93, 1.09)

 Q3: 3

4310

1089 (25.27)

1.05 (0.96, 1.15)

1.04 (0.93, 1.16)

 Q4: >3

189

51 (26.98)

1.15 (0.83, 1.59)

1.24 (0.85, 1.79)

Unweighted GRS for short sleep related SNPs†

1.02 (0.99, 1.04)

1.01 (0.98, 1.04)

 Q1: 0

4756

1128 (23.72)

1.00

1.00

 Q2: 1

11,105

2721 (24.50)

1.04 (0.96, 1.13)

1.05 (0.96, 1.15)

 Q3: 2

10,562

2652 (25.11)

1.08 (1.00, 1.17)

1.07 (0.98, 1.18)

 Q4: >2

6847

1697 (24.78)

1.06 (0.97, 1.16)

1.05 (0.95, 1.16)

Weighted GRS for sleep duration related SNPs†

0.99 (0.97, 1.02)

0.98 (0.95, 1.01)

 Q1: <0.16

8305

2043 (24.60)

1.00

1.00

 Q2: 0.16–0.20

8330

2030 (24.37)

0.99 (0.92, 1.06)

0.97 (0.9, 1.06)

 Q3: 0.21–0.24

8319

2106 (25.32)

1.04 (0.97, 1.12)

1.01 (0.93, 1.10)

 Q4: >0.24

8316

2019 (24.28)

0.98 (0.92, 1.06)

0.95 (0.88, 1.04)

Weighted GRS for long sleep related SNPs†

1.02 (0.99, 1.04)

1.01 (0.99, 1.04)

 Q1: <0.68

6205

1506 (24.27)

1.00

1.00

 Q2: 0.68–0.81

22,566

5552 (24.60)

1.02 (0.95, 1.09)

1.02 (0.94, 1.10)

 Q3: 0.82–1.08

4310

1089 (25.27)

1.06 (0.96, 1.15)

1.05 (0.94, 1.16)

 Q4: >1.08

189

51 (26.98)

1.15 (0.83, 1.60)

1.24 (0.86, 1.80)

Weighted GRS for short sleep related SNPs†

1.01 (0.99, 1.04)

1.00 (0.98, 1.03)

 Q1: <0.09

4756

1128 (23.72)

1.00

1.00

 Q2: 0.09–0.18

10,540

2580 (24.48)

1.04 (0.96, 1.13)

1.05 (0.95, 1.15)

 Q3: 0.19–0.27

9883

2502 (25.32)

1.09 (1.01, 1.18)

1.09 (0.99, 1.19)

 Q4: >0.27

891

1988 (24.57)

1.05 (0.96, 1.14)

1.04 (0.94, 1.14)

  1. GRS: genetic risk score; Q1: the first quartile; Q2: the second quartile; Q3: the third quartile; Q4: the fourth quartile; OR: odds ratio; CI: confidence interval; †: per 1 point OR 95(CI)
  2. Multivariate model was adjusted for covariates that satisfied MR assumption 3, including sociodemographic factors of gender, age, education attainment, marriage status, living alone, life-style behaviors of smoking experience, alcohol drinking, and leisure-time physical activity, albumin and eGFR
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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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