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Table 1 Analysis of bidirectional associations between PTSD and T2D

From: Causal associations between posttraumatic stress disorder and type 2 diabetes

Exposure

Outcome

Method

P_IV

b (se)

OR [95%CI]

N_IV

Q_P

I2

Egger_intercept

P_pleiotropy

P

PTSD

T2D

IVW

1.00E-05

0.035 (0.013)

1.04 [1.01–1.06]

23

1.32E-03

0.536

NA

NA

8.60E-03

PTSD

T2D

WM

1.00E-05

0.019 (0.013)

1.02 [0.99–1.04]

23

NA

NA

NA

NA

0.132

PTSD

T2D

MR-Egger

1.00E-05

-0.009 (0.031)

0.99 [0.93–1.05]

23

3.85E-03

0.48

0.011

0.128

0.766

T2D

PTSD

IVW

5.00E-08

-0.016 (0.039)

0.98 [0.91–1.06]

232

0.058

0.131

NA

NA

0.687

T2D

PTSD

WM

5.00E-08

0.022 (0.064)

1.02 [0.90–1.16]

232

NA

NA

NA

NA

0.729

T2D

PTSD

MR-Egger

5.00E-08

-0.027 (0.091)

0.97 [0.82–1.16]

232

0.053

0.131

0.001

0.894

0.768

  1. IVW: inverse variance weighted; WM: weighted median; OR: odds ratio; CI: confidence interval; N_IV: number of instrumental variables; Q_P: Cochran’s P value of heterogeneity analysis.