Metabolic syndrome including both elevated blood pressure and elevated fasting plasma glucose is associated with higher mortality risk: a prospective study

Table 5 Multivariable mendelian randomization between SBP, DBP, FPG, WC, TG, HDL-C and longevity

Exposure	N (SNPs)	OR (95% CI)	P value	Q value
SBP	99	0.59 (0.40–0.86)	0.006	0.038
DBP	116	1.00 (0.71–1.41)	0.992	0.992
FPG	30	0.68 (0.48–0.98)	0.038	0.113
WC	25	0.83 (0.62–1.12)	0.221	0.265
TG	33	0.88 (0.74–1.03)	0.109	0.163
HDL-C	52	1.14 (0.98–1.33)	0.100	0.163

Abbreviations: SBP, systolic blood pressure; DBP, diastolic blood pressure; FPG, fasting plasma glucose; WC, waist circumferences; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; SNP, single nucleotide polymorphisms; OR, odds ratio; CI, confidence interval. Q value, false discovery rate (FDR) adjusted P value using the Benjamini–Hochberg method

ISSN: 1758-5996