Table 3 GRADE summary of evidence
Certainty assessment | № of patients | Effect | Certainty | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
№ of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | TCEs | Con | Relative (95% CI) | Absolute (95% CI) | ||
FBG | ||||||||||||
35 | randomised trials | serious | not serious | not serious | not serious | none | 916 | 905 | - | MD 0.43 mmol/L lower (0.53 lower to 0.34 lower) | ⨁⨁⨁◯ Moderate | |
HbA1c | ||||||||||||
27 | randomised trials | serious | serious | not serious | not serious | none | 598 | 592 | - | MD 0.28 mmol/L lower (0.38 lower to 0.18 lower) | ⨁⨁◯◯ Low | |
2hPG | ||||||||||||
26 | randomised trials | serious | serious | not serious | not serious | none | 550 | 542 | - | MD 1.16 mmol/L lower (1.48 lower to 0.85 lower) | ⨁⨁◯◯ Low | |
TC | ||||||||||||
7 | randomised trials | serious | not serious | not serious | not serious | none | 188 | 182 | - | MD 0.31 mmol/L lower (0.5 lower to 0.11 lower) | ⨁⨁⨁◯ Moderate | |
TG | ||||||||||||
7 | randomised trials | serious | not serious | not serious | not serious | none | 188 | 182 | - | MD 0.28 mmol/L lower (0.5 lower to 0.06 lower) | ⨁⨁◯◯ Moderate | |
HDL | ||||||||||||
7 | randomised trials | serious | very serious | serious | not serious | none | 188 | 182 | - | MD 0.16 mmol/L higher (0.04 lower to 0.35 higher) | ⨁◯◯◯ Very low | |
LDL | ||||||||||||
7 | randomised trials | serious | not serious | not serious | not serious | none | 188 | 182 | - | MD 0.18 mmol/L lower (0.42 lower to 0.06 higher) | ⨁⨁⨁◯◯ Moderate | |