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Fig. 3 | Diabetology & Metabolic Syndrome

Fig. 3

From: Managing cardiovascular events, hyperglycemia, and obesity in type 2 diabetes through microRNA regulation linked to glucagon-like peptide-1 receptor agonists

Fig. 3

It depicts the molecular interactions and cellular effects of liraglutide in controlling both hyperglycemia and cardiovascular diseases by protecting pancreatic β-cells and endothelial cells. GLP-1RAs downregulate miR-139-5p and miR-34a-5p to protect the cells against apoptosis. Additionally, they counter high glucose-induced Bcl-2 reduction and modulates miR-375 levels, essential for maintaining β-cell function and insulin signaling

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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