Correlation between estimated glucose disposal rate, insulin resistance, and cardiovascular mortality among individuals with metabolic syndrome: a population-based analysis, evidence from NHANES 1999–2018

Table 4 Cox regression analyses for the association between all-cause mortality, CVD mortality and eGDR

subgroups	Model1		Model2		Model3
subgroups	HR (95%CI)	P-value	HR (95%CI)	P-value	HR (95%CI)	P-value
All-cause mortality
eGDR	0.820 (0.812, 0.827)	< 0.001	0.929 (0.907, 0.951)	< 0.001	0.944 (0.912, 0.977)	0.001
eGDR (category)
< 4	1(Ref)		1(Ref)		1(Ref)
4–6	0.757 (0.661, 0.868)	< 0.001	0.664 (0.579, 0.761)	< 0.001	0.710 (0.594, 0.849)	< 0.001
6–8	0.673 (0.577, 0.785)	< 0.001	0.720 (0.617, 0.841)	< 0.001	0.761 (0.611, 0.947)	0.014
> 8	0.435 (0.373, 0.507)	< 0.001	0.589 (0.505, 0.687)	< 0.001	0.644 (0.514, 0.808)	< 0.001
P for trend	0.77 (0.735, 0.807)	< 0.001	0.871 (0.829, 0.915)	< 0.001	0.907 (0.845, 0.973)	0.006
CVD mortality
eGDR	0.841 (0.809, 0.875)	< 0.001	0.877 (0.839, 0.916)	< 0.001	0.906 (0.850, 0.967)	0.003
eGDR (category)
< 4	1(Ref)		1(Ref)		1(Ref)
4–6	0.766 (0.604, 0.971)	0.027	0.665 (0.524, 0.843)	< 0.001	0.736 (0.535, 0.980)	0.049
6–8	0.636 (0.485, 0.835)	0.001	0.685 (0.521, 0.901)	0.007	0.816 (0.552, 1.207)	0.308
> 8	0.298 (0.222, 0.401)	< 0.001	0.406 (0.302, 0.547)	< 0.001	0.525 (0.344, 0.803)	0.003
P for trend	0.689 (0.632, 0.752)	< 0.001	0.774 (0.706, 0.848)	< 0.001	0.845 (0.742, 0.963)	0.011

Model 1: None covariates were adjusted; Model 2: gender and age were adjusted; Model 3, gender, age, race, NLR, TG, drinking, BMI, smoking, TC, moderate physical activities, CVD, diabetes, CKD, ALT, PIR, AST, marital status, uric, and LDL-C were adjusted

ISSN: 1758-5996