Serum triglyceride to high density lipoprotein cholesterol ratio in late pregnancy as a potential predictor of adverse birth outcomes: an analysis of real-world data

Table 4 Accuracy of triglyceride, HDL–C, THR and models to predict ABO

	AUC	95% CI	P value	Best threshold	Specificity (%)	Sensitivity (%)	PPV (%)	NPV (%)
PTB
Triglyceride (mmol/L)	0.601	0.579, 0.622	< 0.001	2.89	73.58	42.91	10.29	94.81
HDL-C (mmol/L)	0.541	0.520, 0.563	< 0.001	1.48	76.62	30.18	8.35	93.95
THR	0.563	0.541, 0.585		1.82	63.46	47.77	8.45	94.51
Model 1	0.745	0.725, 0.764	0.052	-2.32	82.58	56.57	18.68	96.41
Model 2	0.749	0.730, 0.768		-2.35	81.52	57.24	17.97	96.42
SGA
Triglyceride (mmol/L)	0.567	0.548, 0.586	< 0.001	2.96	70.96	39.20	11.59	92.32
HDL–C (mmol/L)	0.559	0.540, 0.578	< 0.001	1.89	70.23	39.10	11.32	92.23
THR	0.580	0.562, 0.599		1.76	67.14	45.26	11.80	92.66
Model 1	0.743	0.727, 0.759	< 0.001	-2.29	69.33	68.69	17.81	95.81
Model 2	0.753	0.738, 0.769		-2.33	68.03	70.58	17.60	95.98
LGA
Triglyceride (mmol/L)	0.587	0.572, 0.601	< 0.001	3.17	38.72	73.83	18.11	88.96
HDL–C (mmol/L)	0.582	0.568, 0.596	< 0.001	1.73	49.77	62.56	18.61	87.86
THR	0.604	0.590, 0.618		2.13	53.23	62.50	19.70	88.55
Model 1	0.734	0.722, 0.746	< 0.001	-1.80	63.91	70.53	26.43	92.18
Model 2	0.745	0.733, 0.757		-1.77	66.36	69.68	27.58	92.25
LBW
Triglyceride (mmol/L)	0.603	0.576, 0.630	< 0.001	2.74	77.60	39.07	7.23	96.61
HDL–C (mmol/L)	0.515	0.487, 0.542	< 0.001	1.48	76.41	29.15	5.23	96.02
THR	0.576	0.549, 0.603		1.51	77.28	35.83	6.58	96.42
Model 1	0.957	0.947, 0.968	0.280	-0.315	91.70	87.91	33.91	99.37
Model 2	0.958	0.948, 0.969		-0.349	89.13	90.57	28.78	99.49
Macrosomia
Triglyceride (mmol/L)	0.614	0.595, 0.633	< 0.001	3.25	40.67	75.79	9.22	95.48
HDL–C (mmol/L)	0.605	0.586, 0.625	< 0.001	1.72	50.27	65.69	9.51	94.85
THR	0.636	0.618, 0.655		2.14	52.57	67.69	10.19	95.34
Model 1	0.786	0.772, 0.801	< 0.001	-2.58	68.79	74.44	16.03	97.11
Model 2	0.800	0.786, 0.814		-2.58	70.10	75.74	16.86	97.30

Notes Model 1 included age, BMI, systolic and diastolic BP, parity, gestational age (except for PTB), pregnancy complications, assisted reproduction, fetal sex and laboratory results (total protein, albumin, total bilirubin, direct bilirubin, ALT, AST, urea nitrogen, creatinine, total cholesterol, LDL–C and hsCRP). Model 2, model 1 plus THR. P values indicated the significance of differences between THR and triglyceride /HDL-C or between Model 1 and Model 2
Abbreviations AUC, area under the curve; CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value; PTB, preterm birth; SGA/LGA, small/large for gestational age; HDL-C, high density lipoprotein cholesterol; THR, triglyceride/HDL-C ratio; ABO, adverse birth outcome; BMI, body mass index; BP, blood pressure; ALT, alanine aminotransferase; AST, aspartate aminotransferase; LDL-C, low density lipoprotein cholesterol; hsCRP, high sensitive C-reactive protein

ISSN: 1758-5996