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Table 3 Mediation analysis to investigate whether prevalent pregnancy complications mediated the association between THR and APO risk a

From: Serum triglyceride to high density lipoprotein cholesterol ratio in late pregnancy as a potential predictor of adverse birth outcomes: an analysis of real-world data

 

PTB

P

SGA

P

LGA

P

LBW

P

Macrosomia

P

Mediation: GDM

      

Total effects (95% CI)

-0.020 (-0.027, -0.013)

< 0.001

-0.030 (-0.037, -0.022)

< 0.001

0.063 (0.054, 0.073)

< 0.001

-0.015 (-0.021, -0.010)

< 0.001

0.043 (0.037, 0.050)

< 0.001

Direct effects (95% CI)

-0.021 (-0.028, -0.014)

< 0.001

-0.029 (-0.036, -0.021)

< 0.001

0.059 (0.050, 0.069)

< 0.001

-0.015 (-0.021, -0.010)

< 0.001

0.042 (0.036, 0.048)

< 0.001

Mediated effects (95% CI)

0.001 (0.000, 0.001)

0.044

-0.001 (-0.002, -0.001)

< 0.001

0.004 (0.003, 0.006)

< 0.001

-0.000 (-0.001, 0.000)

0.474

0.002 (0.001, 0.003)

< 0.001

Mediated Proportion (%)

-3.69

 

3.85

 

6.79

 

1.08

 

4.25

 

Mediation: ICP

      

Total effects (95% CI)

-0.020 (-0.027, -0.013)

< 0.001

-0.030 (-0.037, -0.022)

< 0.001

0.063 (0.054, 0.073)

< 0.001

-0.015 (-0.021, -0.010)

< 0.001

0.043 (0.037, 0.050)

< 0.001

Direct effects (95% CI)

-0.020 (-0.027, -0.014)

< 0.001

-0.030 (-0.038, -0.022)

< 0.001

0.063 (0.054, 0.073)

< 0.001

-0.016 (-0.021, -0.011)

< 0.001

0.043 (0.037, 0.050)

< 0.001

Mediated effects (95% CI)

0.000 (0.000, 0.001)

0.008

0.000 (0.000, 0.001)

0.036

-0.000 (-0.001, 0.000

0.654

0.000 (0.000, 0.001)

0.002

-0.000 (-0.000, 0.000)

0.334

Mediated Proportion

-1.86

 

-0.87

 

0.09

 

-2.09

 

-0.21

 

Mediation: PE

          

Total effects (95% CI)

-0.020 (-0.027, -0.013)

< 0.001

-0.030 (-0.037, -0.022)

< 0.001

0.063 (0.054, 0.073)

< 0.001

-0.015 (-0.021,-0.010)

< 0.001

0.043 (0.037, 0.050)

< 0.001

Direct effects (95% CI)

-0.024 (-0.031, -0.017)

< 0.001

-0.033 (-0.040, -0.025)

< 0.001

0.064 (0.055, 0.074)

< 0.001

-0.019 (-0.025, -0.014)

< 0.001

0.043 (0.038, 0.050)

< 0.001

Mediated effects (95% CI)

0.004 (0.003, 0.006)

< 0.001

0.003 (0.002, 0.005)

< 0.001

-0.000 (-0.001, 0.000)

0.416

0.004 (0.003, 0.006)

< 0.001

-0.000 (-0.001, 0.000)

0.398

Mediated Proportion (%)

-19.77

 

-10.61

 

-0.33

 

-24.57

 

-0.41

 

Mediation: PIH

          

Total effects (95% CI)

-0.020 (-0.027, -0.013)

< 0.001

-0.030 (-0.037, -0.022)

< 0.001

0.063 (0.054, 0.073)

< 0.001

-0.015 (-0.021,-0.010)

< 0.001

0.043 (0.037, 0.050)

< 0.001

Direct effects (95% CI)

-0.020 (-0.027, -0.013)

< 0.001

-0.030 (-0.037, -0.022)

< 0.001

0.063 (0.054, 0.073)

< 0.001

-0.015 (-0.021, -0.010)

< 0.001

0.043 (0.037, 0.050)

< 0.001

Mediated effects (95% CI)

-0.000 (-0.000, 0.000)

0.686

0.000 (-0.000, 0.000)

0.804

0.000 (-0.000, 0.001)

0.134

0.000 (-0.000, 0.000)

0.236

0.000 (0.000, 0.001)

0.044

Mediated Proportion (%)

0.14

 

-0.06

 

0.29

 

-0.56

 

0.56

 
  1. Notes a adjusted forage, BMI, parity, BP, gestational age (except for PTB), assisted reproduction, fetal sex and laboratory results (total protein, albumin, total bilirubin, direct bilirubin, ALT, AST, urea nitrogen, creatinine, total cholesterol, LDL–C and hsCRP)
  2. Abbreviations THR, triglyceride/HDL-C ratio; ABO, adverse birth outcome; CI, confidence interval; PTB, preterm birth; SGA/LGA, small/large for gestational age; BMI, body mass index; LBW, low birth weight; GDM, gestational diabetes mellitus; ICP, intrahepatic cholestasis of pregnancy; PE, pre-eclampsia; PIH, pregnancy induced hypertension; BP, blood pressure; ALT, alanine aminotransferase; AST, aspartate aminotransferase; LDL-C, low density lipoprotein cholesterol; hsCRP, high sensitive C-reactive protein
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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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