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Table 2 Prospective association between the THR and ABO risk in the study population

From: Serum triglyceride to high density lipoprotein cholesterol ratio in late pregnancy as a potential predictor of adverse birth outcomes: an analysis of real-world data

Characteristics

THR

P trend

Per-SD increase in THR

Q1 (Bottom) (< 1.44)

Q2 (1.44–1.88)

Q3 (1.89–2.38)

Q4 (2.39–3.16)

Q5 (Top) (> 3.16)

Median

1.19

1.67

2.11

2.71

3.97

  

PTB

       

No. of cases (percentage)

228 (9.9%)

147 (6.4%)

133 (5.7%)

124 (5.4%)

130 (5.6%)

< 0.001

 

Model 1, OR (95% CI)

1.00

0.62 (0.50, 0.77)

0.55 (0.44, 0.69)

0.52 (0.41, 0.65)

0.54 (0.43, 0.68)

< 0.001

0.86 (0.78, 0.93)

Model 2, OR (95% CI)

1.00

0.62 (0.50, 0.77)

0.57 (0.45, 0.71)

0.51 (0.41, 0.65)

0.54 (0.43, 0.68)

< 0.001

0.86 (0.78, 0.94)

Model 3, OR (95% CI)

1.00

0.58 (0.46, 0.73)

0.58 (0.46, 0.73)

0.52 (0.41, 0.66)

0.52 (0.41, 0.67)

< 0.001

0.84 (0.76, 0.93)

SGA

       

No. of cases (percentage)

300 (13.0%)

208 (9.0%)

199 (8.6%)

165 (7.1%)

151 (6.5%)

< 0.001

 

Model 1, OR (95% CI)

1.00

0.66 (0.55, 0.80)

0.63 (0.52, 0.76)

0.51 (0.42, 0.63)

0.47 (0.38, 0.57)

< 0.001

0.73 (0.67, 0.79)

Model 2, OR (95% CI)

1.00

0.69 (0.57, 0.84)

0.70 (0.58, 0.85)

0.55 (0.45, 0.68)

0.55 (0.45, 0.68)

< 0.001

0.78 (0.71, 0.85)

Model 3, OR (95% CI)

1.00

0.68 (0.56, 0.83)

0.69 (0.56, 0.84)

0.53 (0.43, 0.65)

0.48 (0.38, 0.60)

< 0.001

0.71 (0.65, 0.78)

LGA

       

No. of cases (percentage)

199 (8.6%)

298 (12.9%)

379 (16.4%)

402 (17.4%)

514 (22.2%)

< 0.001

 

Model 1, OR (95% CI)

1.00

1.57 (1.30, 1.89)

2.07 (1.72, 2.48)

2.22 (1.86, 2.66)

3.02 (2.54, 3.60)

< 0.001

1.34 (1.28, 1.40)

Model 2, OR (95% CI)

1.00

1.56 (1.28, 1.90)

1.98 (1.64, 2.40)

2.19 (1.81, 2.64)

2.74 (2.28, 3.29)

< 0.001

1.29 (1.23, 1.35)

Model 3, OR (95% CI)

1.00

1.60 (1.31, 1.95)

2.03 (1.68, 2.46)

2.27 (1.87, 2.75)

2.80 (2.31, 3.40)

< 0.001

1.40 (1.32, 1.49)

LBW

       

No. of cases (percentage)

159 (6.9%)

90 (3.9%)

82 (3.5%)

82 (3.5%)

81 (3.5%)

< 0.001

 

Model 1, OR (95% CI)

1.00

0.55 (0.42, 0.71)

0.50 (0.38, 0.65)

0.50 (0.38, 0.65)

0.49 (0.37, 0.64)

< 0.001

0.77 (0.68, 0.86)

Model 2, OR (95% CI)

1.00

0.68 (0.46, 1.02)

0.75 (0.50, 1.13)

0.82 (0.55, 1.23)

0.77 (0.51, 1.17)

0.426

0.86 (0.75, 0.99)

Model 3, OR (95% CI)

1.00

0.62 (0.41, 0.94)

0.71 (0.46, 1.07)

0.81 (0.54, 1.22)

0.64 (0.41, 1.01)

0.152

0.76 (0.65, 0.90)

Macrosomia

       

No. of cases (percentage)

69 (3.0%)

119 (5.2%)

178 (7.7%)

198 (8.6%)

287 (12.4%)

< 0.001

 

Model 1, OR (95% CI)

1.00

1.75 (1.30, 2.37)

2.67 (2.01, 3.54)

3.01 (2.28, 3.98)

4.53 (3.47, 5.93)

< 0.001

1.38 (1.31, 1.45)

Model 2, OR (95% CI)

1.00

1.59 (1.16, 2.16)

2.46 (1.83, 3.29)

2.50 (1.87, 3.34)

3.75 (2.83, 4.95)

< 0.001

1.34 (1.27, 1.42)

Model 3, OR (95% CI)

1.00

1.59 (1.16, 2.18)

2.50 (1.86, 3.36)

2.52 (1.88, 3.38)

3.80 (2.85, 5.08)

< 0.001

1.49 (1.38, 1.62)

  1. Notes Models 1 were unadjusted. Models 2 were adjusted forage, BMI, parity, BP, gestational age (except for PTB), assisted reproduction and fetal sex. The models 3 were adjusted for covariates in the model 2 and laboratory results (total protein, albumin, total bilirubin, direct bilirubin, ALT, AST, urea nitrogen, creatinine, total cholesterol, LDL–C and hsCRP)
  2. Abbreviations THR, triglyceride/HDL-C ratio; ABO, adverse birth outcome; Q, quintile; PTB, preterm birth; SGA/LGA, small/large for gestational age; LBW, low birth weight; OR, odds ratio; CI, confidence interval; BMI, body mass index; BP, blood pressure; ALT, alanine aminotransferase; AST, aspartate aminotransferase; LDL-C, low density lipoprotein cholesterol; HDL-C, high density lipoprotein cholesterol; hsCRP, high sensitive C-reactive protein
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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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