Table 5 Odds ratio and 95% confidence interval of diabetic retinopathy associated with MEG3 genotypic frequencies in male group
Variable | Non-DKD group (N = 391) | DKD group (N = 380) | AOR (95% CI)# | P value |
|---|---|---|---|---|
rs4081134 | ||||
GG | 217 (55.5%) | 221 (58.2%) | 1.000 (reference) | |
GA | 146 (37.3%) | 139 (36.6%) | 0.942 (0.685–1.296) | 0.714 |
AA | 28 (7.2%) | 20 (5.2%) | 0.712 (0.376–1.347) | 0.297 |
GA + AA | 174 (44.5%) | 159 (41.8%) | 0.904 (0.667–1.226) | 0.518 |
rs10144253 | ||||
TT | 109 (27.9%) | 112 (29.5%) | 1.000 (reference) | |
TC | 195 (49.9%) | 178 (46.8%) | 0.923 (0.647–1.316) | 0.657 |
CC | 87 (22.2%) | 90 (23.7%) | 0.986 (0.656–1.526) | 0.998 |
TC + CC | 282 (72.1%) | 268 (70.5%) | 0.947 (0.678–1.321) | 0.748 |
rs7158663 | ||||
GG | 226 (57.8%) | 211 (55.5%) | 1.000 (reference) | |
GA | 146 (37.3%) | 154 (40.5%) | 1.102 (0.805–1.509) | 0.543 |
AA | 19 (4.9%) | 15 (4.0%) | 1.065 (0.505–2.246) | 0.869 |
GA + AA | 165 (42.2%) | 169 (44.5%) | 1.099 (0.810–1.490) | 0.545 |
rs3087918 | ||||
TT | 107 (27.4%) | 126 (33.2%) | 1.000 (reference) | |
TG | 205 (52.4%) | 191 (50.3%) | 0.848 (0.598–1.201) | 0.353 |
GG | 79 (20.2%) | 63 (16.5%) | 0.630 (0.401–0.990) | 0.045* |
TG + GG | 284 (72.6%) | 254 (66.8%) | 0.784 (0.563–1.091) | 0.149 |
rs11160608 | ||||
AA | 98 (25.1%) | 108 (28.4%) | 1.000 (reference) | |
AC | 207 (52.9%) | 190 (50.0%) | 0.881 (0.613–1.265) | 0.491 |
CC | 86 (22.0%) | 82 (21.6%) | 0.879 (0.567–1.363) | 0.565 |
AC + CC | 293 (74.9%) | 272 (71.6%) | 0.880 (0.624–1.241) | 0.466 |