Table 4 Odds ratio and 95% confidence interval of pre-end stage renal disease associated with MEG3 genotypic frequencies
Variable | Non-DKD group (N = 735) | Pre-ESRD group (N = 158) | AOR (95% CI)# | P value |
|---|---|---|---|---|
rs4081134 | ||||
GG | 419 (57.0%) | 96 (60.8%) | 1.000 (reference) | |
GA | 255 (34.7%) | 54 (34.1%) | 0.828 (0.545–1.260) | 0.379 |
AA | 61 (8.3%) | 8 (5.1%) | 0.592 (0.257–1.365) | 0.219 |
GA + AA | 316 (43.0%) | 62 (39.2%) | 0.784 (0.527–1.167) | 0.230 |
rs10144253 | ||||
TT | 201 (27.3%) | 41 (25.9%) | 1.000 (reference) | |
TC | 370 (50.3%) | 83 (52.5%) | 1.162 (0.731–1.848) | 0.525 |
CC | 164 (22.4%) | 34 (21.6%) | 0.803 (0.452–1.425) | 0.453 |
TC + CC | 534 (72.7%) | 117 (74.1%) | 1.041 (0.670–1.617) | 0.858 |
rs7158663 | ||||
GG | 419 (57.0%) | 89 (56.3%) | 1.000 (reference) | |
GA | 276 (37.6%) | 61 (38.6%) | 0.900 (0.597–1.358) | 0.616 |
AA | 40 (5.4%) | 8 (5.1%) | 1.361 (0.541–3.422) | 0.513 |
GA + AA | 316 (43.0%) | 69 (43.7%) | 0.940 (0.633–1.397) | 0.761 |
rs3087918 | ||||
TT | 209 (28.4%) | 57 (36.1%) | 1.000 (reference) | |
TG | 374 (50.9%) | 69 (43.7%) | 0.900 (0.696–1.163) | 0.420 |
GG | 152 (20.7%) | 32 (20.2%) | 0.639 (0.370–1.106) | 0.110 |
TG + GG | 526 (71.6%) | 101 (63.9%) | 0.637 (0.421–0.962) | 0.032* |
rs11160608 | ||||
AA | 189 (25.7%) | 47 (29.7%) | 1.000 (reference) | |
AC | 376 (51.2%) | 72 (45.6%) | 0.765 (0.482–1.214) | 0.256 |
CC | 170 (23.1%) | 39 (24.7%) | 0.941 (0.551–1.609) | 0.852 |
AC + CC | 546 (74.3%) | 111 (70.3%) | 0.819 (0.532–1.261) | 0.365 |