Table 3 Odds ratio and 95% confidence interval of early diabetic kidney disease associated with MEG3 genotypic frequencies
Variable | Non-DKD group (N = 735) | Early DKD group (N = 548) | AOR (95% CI)# | P value |
|---|---|---|---|---|
rs4081134 | ||||
GG | 419 (57.0%) | 302 (55.1%) | 1.000 (reference) | |
GA | 255 (34.7%) | 207 (37.8%) | 1.176 (0.914–1.513) | 0.206 |
AA | 61 (8.3%) | 39 (7.1%) | 0.961 (0.613–1.509) | 0.864 |
GA + AA | 316 (43.0%) | 246 (44.9%) | 1.135 (0.894–1.440) | 0.298 |
rs10144253 | ||||
TT | 201 (27.3%) | 169 (30.8%) | 1.000 (reference) | |
TC | 370 (50.3%) | 251 (45.8%) | 0.829 (0.629–1.093) | 0.184 |
CC | 164 (22.4%) | 128 (23.4%) | 0.905 (0.652–1.257) | 0.552 |
TC + CC | 534 (72.7%) | 379 (69.2%) | 0.853 (0.659–1.105) | 0.228 |
rs7158663 | ||||
GG | 419 (57.0%) | 329 (60.0%) | 1.000 (reference) | |
GA | 276 (37.6%) | 198 (36.1%) | 0.927 (0.723–1.188) | 0.548 |
AA | 40 (5.4%) | 21 (3.9%) | 0.918 (0.516–1.634) | 0.771 |
GA + AA | 316 (43.0%) | 219 (40.0%) | 0.926 (0.728–1.177) | 0.529 |
rs3087918 | ||||
TT | 209 (28.4%) | 176 (32.1%) | 1.000 (reference) | |
TG | 374 (50.9%) | 283 (51.6%) | 0.970 (0.740–1.271) | 0.825 |
GG | 152 (20.7%) | 89 (16.3%) | 0.722 (0.509–1.025) | 0.068 |
TG + GG | 526 (71.6%) | 372 (67.9%) | 0.896 (0.693–1.158) | 0.401 |
rs11160608 | ||||
AA | 189 (25.7%) | 158 (28.8%) | 1.000 (reference) | |
AC | 376 (51.2%) | 272 (49.6%) | 0.944 (0.713–1.251) | 0.689 |
CC | 170 (23.1%) | 118 (21.6%) | 0.946 (0.675–1.325) | 0.746 |
AC + CC | 546 (74.3%) | 390 (71.2%) | 0.945 (0.724–1.233) | 0.675 |