Table 2 Odds ratio and 95% confidence interval of diabetic kidney disease associated with MEG3 genotypic frequencies
Variable | Non-DKD group (N = 735) | DKD group (N = 706) | AOR (95% CI)# | P value |
|---|---|---|---|---|
rs4081134 | ||||
GG | 419 (57.0%) | 398 (56.4%) | 1.000 (reference) | |
GA | 255 (34.7%) | 261 (37.0%) | 1.085 (0.855–1.378) | 0.503 |
AA | 61 (8.3%) | 47 (6.6%) | 0.863 (0.561–1.329) | 0.505 |
GA + AA | 316 (43.0%) | 308 (43.6%) | 1.042 (0.832–1.306) | 0.720 |
rs10144253 | ||||
TT | 201 (27.3%) | 210 (29.7%) | 1.000 (reference) | |
TC | 370 (50.3%) | 334 (47.3%) | 0.883 (0.679–1.148) | 0.354 |
CC | 164 (22.4%) | 162 (23.0%) | 0.901 (0.658–1.234) | 0.516 |
TC + CC | 534 (72.7%) | 496 (70.3%) | 0.889 (0.695–1.137) | 0.349 |
rs7158663 | ||||
GG | 419 (57.0%) | 418 (59.2%) | 1.000 (reference) | |
GA | 276 (37.6%) | 259 (36.7%) | 0.938 (0.742–1.187) | 0.595 |
AA | 40 (5.4%) | 29 (4.1%) | 0.932 (0.545–1.594) | 0.797 |
GA + AA | 316 (43.0%) | 288 (40.8%) | 0.938 (0.747–1.176) | 0.578 |
rs3087918 | ||||
TT | 209 (28.4%) | 233 (33.0%) | 1.000 (reference) | |
TG | 374 (50.9%) | 352 (49.9%) | 0.900 (0.696–1.163) | 0.420 |
GG | 152 (20.7%) | 121 (17.1%) | 0.703 (0.506–0.975) | 0.035* |
TG + GG | 526 (71.6%) | 473 (67.0%) | 0.840 (0.659–1.072) | 0.161 |
rs11160608 | ||||
AA | 189 (25.7%) | 205 (29.0%) | 1.000 (reference) | |
AC | 376 (51.2%) | 344 (48.7%) | 0.908 (0.695–1.186) | 0.478 |
CC | 170 (23.1%) | 157 (22.3%) | 0.928 (0.675–1.275) | 0.643 |
AC + CC | 546 (74.3%) | 501 (71.0%) | 0.914 (0.710–1.176) | 0.484 |