Table 4 GRADE evidence profile
Outcome | No. of studies | Study Design | No. of participants | Risk of bias | Inconsistency | Indirectness | Imprecision | Publication bias | Plausible confounding | Magnitude of effect | Dose-response gradient | Quality |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Primary Composite Outcome | 8 | RCT | 60,080 | no serious risk | no serious inconsistency | no serious indirectness | no serious imprecision | undetected | would not reduce effect | no | no | High |
Cardiovascular Death | 9 | RCT | 63,613 | no serious risk | no serious inconsistency | no serious indirectness | no serious imprecision | undetected | would not reduce effect | no | no | High |
All-Cause Death | 9 | RCT | 63,613 | no serious risk | no serious inconsistency | no serious indirectness | no serious imprecision | undetected | would not reduce effect | no | no | High |
Myocardial Infarction | 9 | RCT | 63,613 | no serious risk | no serious inconsistency | no serious indirectness | no serious imprecision | undetected | would not reduce effect | no | no | High |
HF Hospitalization | 9 | RCT | 63,613 | no serious risk | no serious inconsistency | no serious indirectness | no serious imprecision | undetected | would not reduce effect | no | no | High |
Stroke | 9 | RCT | 63,613 | no serious risk | no serious inconsistency | no serious indirectness | no serious imprecision | undetected | would not reduce effect | no | no | High |
UA Hospitalization | 7 | RCT | 50,617 | no serious risk | no serious inconsistency | no serious indirectness | serious imprecision | undetected | would not reduce effect | no | no | Moderate |