New insights on genetic background of major diabetic vascular complications

Table 5 Comparison between serum and plasma MiRNA samples in Diabetic Retinopathy

Sample	miRNA	Target	Function	Phenotype	Refs.
Intracellular miRNA	miR-21	EC dysfunction	Pathogenic \(\to\) inflammation	DR	[98]
	miR-216a	Suppression of NOS2/JAK/STAT	Protective effect \(\to\) HRMECs	DR	[104]
	miR-29b-3p	Blocking SIRT1	Pathogenic effect \(\to\) HRMEC apoptosis	DR	[105]
	miR-203a-3p	VEGFA, HIF-1α	Inhibits angiogenesis	PDR	[102]
	miR-200b	VEGF	Inhibits VEGF	DR	[106]
Circulatory miRNA	miR210	EC proliferation	Upregulation Biomarker for PDR vs. NPDR	DR	[100]
	miR320a		Protective effect \(\to\) increased expression of endothelin 1 (ET-1), vascular endothelial growth factor (VEGF), and fibronectin (FN) in human umbilical vein endothelial cells (HUVECs)	DR	[103]

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