Table 3 Associations of APOE genes polymorphisms and the risk of obesity with and without T2DM
APOE genotyping & allele | Obese cases vs. control | obese cases with T2DM vs. control | Obese cases without and with T2DM | |||
|---|---|---|---|---|---|---|
OR (95%CI) | p-value | OR (95%CI) | p-value | OR (95%CI) | p-value | |
E3/E3 (ref) | - | - | - | - | - | - |
E2/E2 | 1.231 (0.973–1.557) | 0.048 | 1.412 (1.092–1.825) | 0.010 | 0.293 (0.064–1.348) | 0.104 |
E2/E3 | 2.533 (0.980–6.547) | 0.053 | 0.974 (0.335–2.831) | 0.962 | 1.779 0.645–4.907 | 0.264 |
E2/E4 | 0.804 (0.290–2.228) | 0.674 | 1.608 (0.635–4.074) | 0.316 | 0.622 0.245–1.576 | 0.316 |
E3/E4 | 0.985 (0.425–2.281) | 0.972 | 0.985 (0.425–2.281) | 0.972 | 1.015 0.438–2.351 | 0.972 |
E4/E4 | - | - | 2.308 (1.533–3.475) | < 0.001 | 0.433 (0.288–0.652) | < 0.001 |
E3 (ref) | - | - | - | - | - | - |
E2 | 2.542 (1.540–4.197) | < 0.001 | 1.942 (1.134–3.326) | 0.015 | 0.764 (0.466–1.251) | 0.284 |
E4 | 0.949 (0.592–1.522) | 0.829 | 1.948 (1.248–3.041) | 0.003 | 2.052 (1.274–3.304) | 0.003 |