Exploring genetic association of systemic iron status and risk with incidence of diabetic neuropathy

Table 1 SNPs from GWAS on systemic iron status and diabetic neuropathy

SNP	EA	OA	Exposure (Iron status)
SNP	EA	OA	β	SE	p value	β	SE	p value
Iron
rs1525892	A	G	0.074	0.010	1.65E-12	0.062	0.042	0.142
rs1800562	A	G	0.372	0.020	3.96E-77	-0.123	0.102	0.229
rs855791	G	A	0.187	0.010	4.31E-77	0.010	0.041	0.808
Ferritin
rs12693541	T	C	-0.106	0.014	4.18E-14	0.077	0.062	0.215
rs1800562	A	G	0.211	0.019	1.42E-29	-0.123	0.102	0.229
rs368243	C	T	-0.051	0.009	3.80E-08	0.038	0.039	0.329
rs2413450	C	T	0.056	0.010	3.57E-09	-0.002	0.040	0.966
Transferrin
rs744653	T	C	0.092	0.014	2.00E-10	0.092	0.055	0.720
rs9990333	T	C	-0.067	0.010	3.01E-11	-0.067	0.040	0.266
rs17376530	T	C	-0.188	0.017	5.43E-30	-0.188	0.059	0.653
rs1800562	A	G	-0.550	0.021	1.26E-153	-0.550	0.102	0.229
rs174577	A	C	0.068	0.011	1.90E-10	0.068	0.040	0.025
Transferrin saturation
rs8177272	A	G	-0.097	0.011	5.52E-20	0.062	0.042	0.142
rs1800562	A	G	0.577	0.020	1.52E-178	-0.123	0.102	0.229
rs221834	G	C	0.123	0.021	2.38E-09	0.021	0.082	0.796
rs855791	G	A	0.192	0.010	3.50E-80	0.010	0.041	0.808

SNP: single nucleotide polymorphisms; EA: effect allele; OA: other allele; SE, standard error. Iron status biomarkers data are publicly accessible via the Genetics of Iron Status Consortium at https://doi.org/10.1038/ncomms5926. Diabetic neuropathy data are openly available in FinnGen at https://www.finngen.fi/en

ISSN: 1758-5996