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Table 5 Subgroup analysis of 90-day mortality among patients

From: Independent effects of the glucose-to-glycated hemoglobin ratio on mortality in critically ill patients with atrial fibrillation

Subgroup

Variable

Total

Event (%)

HR (95CI)

P value

P for interaction

Age

     

0.334

  < 65

Tertile1

233

23 (9.9)

1.88 (0.85 ~ 4.16)

0.117

 

Tertile2

233

9 (3.9)

1(Ref)

  

Tertile3

239

24 (10)

3.2 (1.44 ~ 7.11)

0.004

 

Trend test

705

56 (7.9)

1.3 (0.93 ~ 1.83)

0.13

 

  ≥ 65

Tertile1

857

164 (19.1)

1.34 (1.04 ~ 1.73)

0.022

 

Tertile2

866

102 (11.8)

1(Ref)

  

Tertile3

857

172 (20.1)

2.02 (1.58 ~ 2.59)

 < 0.001

 

Trend test

2580

438 (17)

1.23 (1.09 ~ 1.39)

0.001

 

Gender

     

0.939

 Female

Tertile1

457

96 (21)

1.39 (1 ~ 1.94)

0.052

 

Tertile2

424

59 (13.9)

1(Ref)

  

Tertile3

407

102 (25.1)

2.16 (1.56 ~ 2.99)

 < 0.001

 

Trend test

1288

257 (20)

1.26 (1.07 ~ 1.47)

0.005

 

 Male

Tertile1

633

91 (14.4)

1.48 (1.04 ~ 2.09)

0.028

 

Tertile2

675

52 (7.7)

1(Ref)

  

Tertile3

689

94 (13.6)

2.27 (1.6 ~ 3.22)

 < 0.001

 

Trend test

1997

237 (11.9)

1.24 (1.05 ~ 1.46)

0.009

 

Race

     

0.855

 White

Tertile1

692

115 (16.6)

1.63 (1.2 ~ 2.21)

0.002

 

Tertile2

765

68 (8.9)

1(Ref)

  

Tertile3

728

109 (15)

2.12 (1.55 ~ 2.88)

 < 0.001

 

Trend test

2185

292 (13.4)

1.13 (0.97 ~ 1.31)

0.104

 

 Black

Tertile1

61

11 (18)

1.14 (0.4 ~ 3.25)

0.803

 

Tertile2

47

6 (12.8)

1(Ref)

  

Tertile3

41

14 (34.1)

3.18 (1.12 ~ 9.05)

0.03

 

Trend test

149

31 (20.8)

1.67 (1.06 ~ 2.66)

0.029

 

 Other

Tertile1

337

61 (18.1)

1.16 (0.77 ~ 1.77)

0.477

 

Tertile2

287

37 (12.9)

1(Ref)

  

Tertile3

327

73 (22.3)

1.99 (1.33 ~ 2.99)

0.001

 

Trend test

951

171 (18)

1.32 (1.1 ~ 1.59)

0.003

 

BMI

     

0.365

  ≤ 24.9

Tertile1

275

73 (26.5)

1.58 (1.06 ~ 2.35)

0.025

 

Tertile2

259

39 (15.1)

1(Ref)

  

Tertile3

215

53 (24.7)

1.97 (1.28 ~ 3.02)

0.002

 

Trend test

749

165 (22)

1.08 (0.89 ~ 1.32)

0.438

 

 25–30

Tertile1

347

53 (15.3)

1.6 (1.02 ~ 2.5)

0.04

 

Tertile2

376

33 (8.8)

1(Ref)

  

Tertile3

373

55 (14.7)

2.35 (1.5 ~ 3.68)

 < 0.001

 

Trend test

1096

141 (12.9)

1.22 (0.98 ~ 1.51)

0.08

 

  > 30

Tertile1

468

61 (13)

1.18 (0.78 ~ 1.78)

0.432

 

Tertile2

464

39 (8.4)

1(Ref)

  

Tertile3

508

88 (17.3)

2.28 (1.56 ~ 3.35)

 < 0.001

 

Trend test

1440

188 (13.1)

1.43 (1.2 ~ 1.72)

 < 0.001

 

Hypertension

     

0.527

 No

Tertile1

614

123 (20)

1.41 (1.03 ~ 1.92)

0.03

 

Tertile2

519

63 (12.1)

1(Ref)

  

Tertile3

495

99 (20)

1.99 (1.44 ~ 2.75)

 < 0.001

 

Trend test

1628

285 (17.5)

1.17 (1.01 ~ 1.35)

0.037

 

 Yes

Tertile1

476

64 (13.4)

1.38 (0.94 ~ 2.03)

0.098

 

Tertile2

580

48 (8.3)

1(Ref)

  

Tertile3

601

97 (16.1)

2.21 (1.55 ~ 3.14)

 < 0.001

 

Trend test

1657

209 (12.6)

1.32 (1.1 ~ 1.57)

0.003

 

Heart failure

     

0.935

 No

Tertile1

522

79 (15.1)

1.32 (0.92 ~ 1.88)

0.131

 

Tertile2

637

54 (8.5)

1(Ref)

  

Tertile3

698

114 (16.3)

2.15 (1.54 ~ 2.99)

 < 0.001

 

Trend test

1857

247 (13.3)

1.32 (1.12 ~ 1.55)

0.001

 

 Yes

Tertile1

568

108 (19)

1.41 (1.01 ~ 1.95)

0.041

 

Tertile2

462

57 (12.3)

1(Ref)

  

Tertile3

398

82 (20.6)

2.11 (1.5 ~ 2.98)

 < 0.001

 

Trend test

1428

247 (17.3)

1.2 (1.02 ~ 1.41)

0.025

 

Cancer

     

0.265

 No

Tertile1

894

135 (15.1)

1.21 (0.91 ~ 1.6)

0.186

 

Tertile2

901

84 (9.3)

1(Ref)

  

Tertile3

938

171 (18.2)

2.22 (1.7 ~ 2.9)

 < 0.001

 

Trend test

2733

390 (14.3)

1.38 (1.22 ~ 1.57)

 < 0.001

 

 Yes

Tertile1

196

52 (26.5)

2.07 (1.28 ~ 3.34)

0.003

 

Tertile2

198

27 (13.6)

1(Ref)

  

Tertile3

158

25 (15.8)

1.47 (0.83 ~ 2.59)

0.183

 

Trend test

552

104 (18.8)

0.78 (0.6 ~ 1.01)

0.064

 

CKD

     

0.429

 No

Tertile1

769

119 (15.5)

1.64 (1.22 ~ 2.2)

0.001

 

Tertile2

898

74 (8.2)

1(Ref)

  

Tertile3

910

142 (15.6)

2.35 (1.77 ~ 3.13)

 < 0.001

 

Trend test

2577

335 (13)

1.22 (1.06 ~ 1.4)

0.005

 

 Yes

Tertile1

321

68 (21.2)

1.07 (0.71 ~ 1.61)

0.738

 

Tertile2

201

37 (18.4)

1(Ref)

  

Tertile3

186

54 (29)

1.73 (1.12 ~ 2.67)

0.014

 

Trend test

708

159 (22.5)

1.25 (1.03 ~ 1.52)

0.023

 

AKI

     

0.858

 No

Tertile1

663

77 (11.6)

1.4 (0.99 ~ 1.99)

0.057

 

Tertile2

809

58 (7.2)

1(Ref)

  

Tertile3

869

123 (14.2)

2.17 (1.59 ~ 2.98)

 < 0.001

 

Trend test

2341

258 (11)

1.3 (1.11 ~ 1.53)

0.001

 

 Yes

Tertile1

427

110 (25.8)

1.47 (1.05 ~ 2.06)

0.025

 

Tertile2

290

53 (18.3)

1(Ref)

  

Tertile3

227

73 (32.2)

2.3 (1.59 ~ 3.31)

 < 0.001

 

Trend test

944

236 (25)

1.2 (1.02 ~ 1.42)

0.027

 

Stroke

     

0.557

 No

Tertile1

954

153 (16)

1.41 (1.08 ~ 1.86)

0.013

 

Tertile2

915

83 (9.1)

1(Ref)

  

Tertile3

920

153 (16.6)

2.24 (1.71 ~ 2.93)

 < 0.001

 

Trend test

2789

389 (13.9)

1.26 (1.11 ~ 1.43)

 < 0.001

 

 Yes

Tertile1

136

34 (25)

1.53 (0.9 ~ 2.58)

0.115

 

Tertile2

184

28 (15.2)

1(Ref)

  

Tertile3

176

43 (24.4)

2.11 (1.27 ~ 3.52)

0.004

 

Trend test

496

105 (21.2)

1.2 (0.92 ~ 1.56)

0.18

 
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