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Fig. 3 | Diabetology & Metabolic Syndrome

Fig. 3

From: Adipose stem cells-derived small extracellular vesicles transport Thrombospondin 1 cargo to promote insulin resistance in gestational diabetes mellitus

Fig. 3

Proteomic identification of high Thbs1 expression in ADSC/GDM-derived sEV. A Venn diagram of the number of proteins detected by unlabeled protein profiles for and sEVA (AD in graph) and sEVAG (ADGDM in graph). B The number of proteins with high and low expression in sEVAG. C Volcanic map of differentially expressed protein in sEVAG. D GO signaling pathway analysis of sEVA and sEVAG proteins. E KEGG signal analysis of sEVA and sEVAG proteins. F GSEA analysis revealed enrichment of the ECm-receptor interaction pathway. G Network analysis of interactions between differential ECM regulatory proteins and other differential proteins. H. Heat maps of 10 proteins significantly overexpressed in sEVAG. I, J Mass spectrometry quantification and western blotting of Thbs1 in sEVA and sEV.AG. ***P < 0.001

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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